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Volume 42 Issue 5, May 2021

Volume 42 Issue 5

Drp1 can be SUMOylated by both SUMO-1 and SUMO-2/3. SUMO-1-ylation and deSUMO-2/3-ylation of Drp1 promotes its association with mitochondrial outer membrane (MOM), which facilitates mitochondrial fission and activates mitophagy. On the contrary, SUMO-2/3-ylation and deSUMO-1-ylation of Drp1 lead to accumulation of defective mitochondria and cardiomyocyte apoptosis.

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