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Volume 42 Issue 1, January 2021

Immunotherapy has achieved great outcome in clinic, and PD-1/PD-L1 immunotherapy is the most promising one. Due to the limitations of monoclonal antibodies, the discovery of small molecule drugs blocking PD-1/PD-L1 signaling has attracted great interest. In this issue, Wu et al summarized the advances in small molecule inhibitors targeting the PD-1/PD-L1.

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