Volume 41 Issue 9, September 2020

Shuanghuanglian preparations and bioactive ingredients including baicalin and baicalein dose-dependently inhibited SARS-CoV-2 3CL protease and the replication of SARS-CoV-2 in cells. The crystal structure of SARS-CoV-2 3CL protease in complex with baicalein revealed a unique binding mode of this bioflavonoid as the first noncovalent, nonpeptidomimetic inhibitor of the protease.

Review Article

Overview of therapeutic drug research for COVID-19 in China

Heng Li
Li Yang
Jian-ping Zuo

Collections:

40 years of APS

Covid-19: The Molecular Mechanism and Drug Research
Review Article 17 Jun 2020
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Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Yuan Huang
Chan Yang
Shu-wen Liu

Collections:

40 years of APS

Covid-19: The Molecular Mechanism and Drug Research
Review Article 03 Aug 2020

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Article

sFRP1 protects H9c2 cardiac myoblasts from doxorubicin-induced apoptosis by inhibiting the Wnt/PCP-JNK pathway

Yue-huai Hu
Jie Liu
Pei-qing Liu
Article 01 Apr 2020
Ritanserin blocks Ca_V1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies

Fabio Fusi
Alfonso Trezza
Sergio Bova
Article 04 Mar 2020
Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

Hai-xia Su
Sheng Yao
Ye-chun Xu

Focus:

Covid-19: The Molecular Mechanism and Drug Research
Article 31 Jul 2020
β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling

Bei-xian Zhou
Jing Li
Nan-shan Zhong
Article 05 Jun 2020
Heterozygous SOD2 deletion deteriorated chronic intermittent hypoxia-induced lung inflammation and vascular remodeling through mtROS-NLRP3 signaling pathway

Jie-qiong Song
Li-yan Jiang
Shan-qun Li
Article 17 Feb 2020
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53

Marwan Almoiliqy
Jin Wen
Yuan Lin
Article 01 Apr 2020
RIP1 promotes proliferation through G2/M checkpoint progression and mediates cisplatin-induced apoptosis and necroptosis in human ovarian cancer cells

Xue-lian Zheng
Jiao-jiao Yang
Yong Lin
Article 02 Apr 2020
Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization

Bo-ya Zhou
Wen-bo Wang
Wei Liu
Article 23 Apr 2020
The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L

Bing-bing Hao
Xiao-jing Li
Min-jia Tan
Article 24 Mar 2020

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Correspondence

Recombinant human ACE2: potential therapeutics of SARS-CoV-2 infection and its complication

Xiaocong Pang
Yimin Cui
Yizhun Zhu

Collections:

40 years of APS

Covid-19: The Molecular Mechanism and Drug Research
Correspondence 24 Jun 2020
Cobrotoxin could be an effective therapeutic for COVID-19

Fang Lin
Paul F. Reid
Zheng-hong Qin

Collections:

40 years of APS

Covid-19: The Molecular Mechanism and Drug Research
Correspondence 25 Aug 2020

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Correction

Author Correction: Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells

Jing-jing Zhu
Xin-xin Zhang
Yong Gan
Correction 21 Feb 2020

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Retraction

Retraction Note: Resveratrol rescues hyperglycemia-induced endothelial dysfunction via activation of Akt

Jin-yi Li
Wei-qiang Huang
Yan He
Retraction 17 Jan 2020

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Volume 41 Issue 9, September 2020

Review Article

Overview of therapeutic drug research for COVID-19 in China

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Article

sFRP1 protects H9c2 cardiac myoblasts from doxorubicin-induced apoptosis by inhibiting the Wnt/PCP-JNK pathway

Ritanserin blocks Ca_V1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies

Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling

Heterozygous SOD2 deletion deteriorated chronic intermittent hypoxia-induced lung inflammation and vascular remodeling through mtROS-NLRP3 signaling pathway

Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53

RIP1 promotes proliferation through G2/M checkpoint progression and mediates cisplatin-induced apoptosis and necroptosis in human ovarian cancer cells

Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization

The novel cereblon modulator CC-885 inhibits mitophagy via selective degradation of BNIP3L

Correspondence

Recombinant human ACE2: potential therapeutics of SARS-CoV-2 infection and its complication

Cobrotoxin could be an effective therapeutic for COVID-19

Correction

Author Correction: Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells

Retraction

Retraction Note: Resveratrol rescues hyperglycemia-induced endothelial dysfunction via activation of Akt

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