Volume 41 Issue 5, May 2020

Precision medicine based on molecular signatures of patients has shown increasing value in cancer treatment. This review summarized the common strategies of CRISPR-cas9 screening and the application of this screening in precision medicine including identification of new targets and biomarkers and elucidation of mechanisms leading to drug resistance.

Review Article

CRISPR-cas9: a powerful tool towards precision medicine in cancer treatment

Hui Xing
Ling-hua Meng
Review Article 02 Dec 2019
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Article

Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation

Wen-xuan Jian
Zhao Zhang
Nai-hong Chen
Article 08 Jan 2020
DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss

Wei Zhou
Wen-wen Lian
Guan-hua Du
Article 04 Nov 2019
Adipose-derived mesenchymal stem cells protect against CMS-induced depression-like behaviors in mice via regulating the Nrf2/HO-1 and TLR4/NF-κB signaling pathways

Xiao Huang
Guo-qiang Fei
Xin Wang
Article 03 Dec 2019
Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea

Lin Yang
Jing Zhao
Jing Ai
Article 20 Dec 2019
Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels

Zhu-qing Xie
Xiao-ting Tian
Zhao-bing Gao
Article 07 Jan 2020
Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms

Hai-tao Yu
Juan Zhen
Bradley B Keller
Article 25 Nov 2019
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats

Bei-bo Cai
Yi-ni Lu
Ming Xu
Article 17 Dec 2019
A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression

Na Zhang
Shuang-shuang Zhao
Hong-wei He
Article 13 Jan 2020
Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

Xiao-qiang Geng
Ang Ma
Bao-xue Yang
Article 05 Dec 2019
Fecal microbiota transplantation improves metabolism and gut microbiome composition in db/db mice

Pei-pei Zhang
Lin-lin Li
Ye Wang
Article 14 Jan 2020
The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation

Wu-li Zhao
Yan Xing
Rong-guang Shao
Article 13 Jan 2020
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity

Le-le Zhang
Jing Guo
Jin-jian Lu
Article 11 Feb 2020
[1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a new NS5-RdRp inhibitor of DENV2 proliferation and DENV2-induced inflammation

Yi-hong Wan
Wen-yu Wu
Xin-gang Yao
Article 15 Nov 2019
PK/PD modeling based on NO-ET homeostasis for improving management of sunitinib-induced hypertension in rats

Hao-chen Liu
Xiao-ting Zhou
Xiao-quan Liu
Article 13 Jan 2020

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Correction

Publisher Correction: Integrating yeast chemical genomics and mammalian cell pathway analysis

Fu-lai Zhou
Sheena C Li
Ming-wei Wang
Correction 21 Feb 2020
Author Correction: The natural product 4,10-aromadendranediol induces neuritogenesis in neuronal cells in vitro through activation of the ERK pathway

Sai Chang
Wen-chen Ruan
Tao Pang
Correction 21 Feb 2020
Author Correction: Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells

Yue-qin Wang
Ai-jun Shen
Jian Ding
Correction 21 Feb 2020
Author Correction: AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition

Kai-li Zhang
Qian-qian Shen
Yi Chen
Correction 14 Feb 2020

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Volume 41 Issue 5, May 2020

Review Article

CRISPR-cas9: a powerful tool towards precision medicine in cancer treatment

Article

Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation

DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss

Adipose-derived mesenchymal stem cells protect against CMS-induced depression-like behaviors in mice via regulating the Nrf2/HO-1 and TLR4/NF-κB signaling pathways

Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea

Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels

Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms

Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats

A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

Fecal microbiota transplantation improves metabolism and gut microbiome composition in db/db mice

The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation

Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity

[1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a new NS5-RdRp inhibitor of DENV2 proliferation and DENV2-induced inflammation

PK/PD modeling based on NO-ET homeostasis for improving management of sunitinib-induced hypertension in rats

Correction

Publisher Correction: Integrating yeast chemical genomics and mammalian cell pathway analysis

Author Correction: The natural product 4,10-aromadendranediol induces neuritogenesis in neuronal cells in vitro through activation of the ERK pathway

Author Correction: Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells

Author Correction: AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition

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