Acta Pharmacologica Sinica

Structure genomics of SARS-CoV-2 and its Omicron variant

Targeted degradation of membrane and extracellular proteins with LYTACs

Yu-yang Li
Yang Yang
Song-bo Xie

Review Article 05 August 2024

Featured

The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca²⁺ transport in the pathogenesis of diseases

Wen-bin Zhao
Rui Sheng
Review Article08 Aug 2024
Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice

Alejandro Serrano
Noelia Casares
María J. Garrido
ArticleOpen Access29 Jul 2024
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity

Yin-yan Li
Guo-dong Liang
Jie Yang
Article10 Jul 2024
Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice

Bi-xi Tang
Yong Zhang
Yi Zang
Article05 Aug 2024

Current issue

Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis

Ana Beatriz Santos
Andreia Carona
Joana Bicker
Review Article29 Apr 2024
Insomnia-related rodent models in drug discovery

Ze-ka Chen
Yuan-yuan Liu
Zhi-li Huang
Review Article26 Apr 2024
E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

Chun-yan Duan
Yue Li
Guoqiang Xu
Article13 May 2024
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy

Xiao-lu Jiang
Zu-bin Zhang
Mei Li
Article15 May 2024
Sodium oligomannate activates the enteroendocrine-vagal afferent pathways in APP/PS1 mice

Hua-shan Gong
Jing-pei Pan
Wei-fang Rong
Article03 May 2024
Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E₂ in the lateral parabrachial nucleus of male rats

Jian-hui Xu
Tian-hui He
Jie Zhang
Article03 May 2024

Contents

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Announcements

JOIN US | Deputy Director Position of SKLDR

State Key Laboratory of Drug Research (SKLDR), which was approved by Chinese Academy of Sciences under the unremitting efforts of reorganizing the state key laboratory system, is recruiting a Deputy Director. The candidate is expected to help SKLDR to continuously improve the academic influence and the ability to transform new drug achievements into real productivity.

Browse articles

Palmitoyltransferase ZDHHC3 is essential for the oncogenic activity of PML/RARα in acute promyelocytic leukemia

Xue-jing Shao
Wei Wang
Bo Yang
Article03 Sept 2024
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle

Sha-sha Wang
Ye Peng
Nai-hong Chen
Article03 Sept 2024
Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages

Yi-ping You
Liang Yan
Xian-hui He
Article02 Sept 2024
INHBA promotes tumor growth and induces resistance to PD-L1 blockade by suppressing IFN-γ signaling

Fang-lin Li
Long-hua Gu
Li-kun Gong
Article02 Sept 2024
Preclinical characterization of [¹⁸F]D₂-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates

Kai Liao
Jia-hui Chen
Lu Wang
Article29 Aug 2024
Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer

Zi-yang Liu
Ya-wen Zhang
Xin-liang Mao
Article28 Aug 2024
Chromosome instability functions as a potential therapeutic reference by enhancing chemosensitivity to BCL-XL inhibitors in colorectal carcinoma

Xiao Fang
Wen-ying Yu
Ya Zhao
Article26 Aug 2024
LPA suppresses HLA-DR expression in human melanoma cells: a potential immune escape mechanism involving LPAR1 and DR6-mediated release of IL-10

Enikő Major
Kuan-Hung Lin
Zoltán Benyó
Brief CommunicationOpen Access26 Aug 2024
Vinpocetine alleviates the abdominal aortic aneurysm progression via VSMCs SIRT1-p21 signaling pathway

Hong-qin Yang
Zhi-wei Li
Hong-mei Zhao
Article23 Aug 2024

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Science jobs

Postdoctoral Associate- Genetic Epidemiology

Houston, Texas (US)

Baylor College of Medicine (BCM)
NOMIS Foundation ETH Postdoctoral Fellowship

The NOMIS Foundation ETH Fellowship Programme supports postdoctoral researchers at ETH Zurich within the Centre for Origin and Prevalence of Life ...

Zurich, Canton of Zürich (CH)

Centre for Origin and Prevalence of Life at ETH Zurich
13 PhD Positions at Heidelberg University

GRK2727/1 – InCheck Innate Immune Checkpoints in Cancer and Tissue Damage

Heidelberg, Baden-Württemberg (DE) and Mannheim, Baden-Württemberg (DE)

Medical Faculties Mannheim & Heidelberg and DKFZ, Germany
Postdoctoral Associate- Environmental Epidemiology

Houston, Texas (US)

Baylor College of Medicine (BCM)
Open Faculty Positions at the State Key Laboratory of Brain Cognition & Brain-inspired Intelligence

The laboratory focuses on understanding the mechanisms of brain intelligence and developing the theory and techniques of brain-inspired intelligence.

Shanghai, China

CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT)

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

Targeted degradation of membrane and extracellular proteins with LYTACs

Featured

The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca²⁺ transport in the pathogenesis of diseases

Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice

A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity

Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice

Current issue

Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis

Insomnia-related rodent models in drug discovery

E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy

Sodium oligomannate activates the enteroendocrine-vagal afferent pathways in APP/PS1 mice

Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E₂ in the lateral parabrachial nucleus of male rats

Announcements

JOIN US | Deputy Director Position of SKLDR

Browse articles

Palmitoyltransferase ZDHHC3 is essential for the oncogenic activity of PML/RARα in acute promyelocytic leukemia

Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle

Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages

INHBA promotes tumor growth and induces resistance to PD-L1 blockade by suppressing IFN-γ signaling

Preclinical characterization of [¹⁸F]D₂-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates

Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer

Chromosome instability functions as a potential therapeutic reference by enhancing chemosensitivity to BCL-XL inhibitors in colorectal carcinoma

LPA suppresses HLA-DR expression in human melanoma cells: a potential immune escape mechanism involving LPAR1 and DR6-mediated release of IL-10

Vinpocetine alleviates the abdominal aortic aneurysm progression via VSMCs SIRT1-p21 signaling pathway

Trending - Altmetric

Science jobs

Postdoctoral Associate- Genetic Epidemiology

NOMIS Foundation ETH Postdoctoral Fellowship

13 PhD Positions at Heidelberg University

Postdoctoral Associate- Environmental Epidemiology

Open Faculty Positions at the State Key Laboratory of Brain Cognition & Brain-inspired Intelligence

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Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Organ preservation: from the past to the future

LPA suppresses HLA-DR expression in human melanoma cells: a potential immune escape mechanism involving LPAR1 and DR6-mediated release of IL-10

Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression

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