Acta Pharmacologica Sinica

Structure genomics of SARS-CoV-2 and its Omicron variant

Targeted degradation of membrane and extracellular proteins with LYTACs

Yu-yang Li
Yang Yang
Song-bo Xie

Review Article 05 August 2024

Featured

The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca²⁺ transport in the pathogenesis of diseases

Wen-bin Zhao
Rui Sheng
Review Article08 Aug 2024
Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice

Alejandro Serrano
Noelia Casares
María J. Garrido
ArticleOpen Access29 Jul 2024
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity

Yin-yan Li
Guo-dong Liang
Jie Yang
Article10 Jul 2024
Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice

Bi-xi Tang
Yong Zhang
Yi Zang
Article05 Aug 2024

Current issue

The role of the cGAS-STING signaling pathway in viral infections, inflammatory and autoimmune diseases

Ming-ming Wang
Yue Zhao
Ting Li
Review Article01 Jun 2024
Targeting metabolism to enhance immunotherapy within tumor microenvironment

Xiao-hui Liang
Xin-yi Chen
Xin Luan
Review Article29 May 2024
Endothelial dysfunction: mechanisms and contribution to diseases

Amir Ajoolabady
Domenico Pratico
Jun Ren
Perspective21 May 2024
Hepatic kynurenic acid mediates phosphorylation of Nogo-A in the medial prefrontal cortex to regulate chronic stress-induced anxiety-like behaviors in mice

Lan Yan
Wen-jing Wang
Li Zhang
Article29 May 2024
Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice

Yong-sheng Zhou
Hao-bo Tao
Qian-ru Zhao
Article11 Jun 2024
Desloratadine ameliorates paclitaxel-induced peripheral neuropathy and hypersensitivity reactions in mice

Jian Lu
Xue-jian Zhao
Xu Shen
Article24 May 2024

Volume 45 Issue 10

Contents

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Announcements

JOIN US | Deputy Director Position of SKLDR

State Key Laboratory of Drug Research (SKLDR), which was approved by Chinese Academy of Sciences under the unremitting efforts of reorganizing the state key laboratory system, is recruiting a Deputy Director. The candidate is expected to help SKLDR to continuously improve the academic influence and the ability to transform new drug achievements into real productivity.

Browse articles

A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth

Qing-yong Hu
Lei Li
Yang Cao
Article09 Oct 2024
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5

Tian-tian Wang
Long-long Zhang
Ce-shi Chen
Article08 Oct 2024
AI-driven antibody design with generative diffusion models: current insights and future directions

Xin-heng He
Jun-rui Li
H. Eric Xu
Review Article30 Sept 2024
β-arrestin2: an emerging player and potential therapeutic target in inflammatory immune diseases

Ping-ping Gao
Ling Li
Wu-yi Sun
Review Article30 Sept 2024
¹⁹F qNMR based pharmacokinetics, metabolism and mass balance studies of SARS-CoV-2-3CL protease inhibitor simnotrelvir (SIM0417) in humans

Ze-yu Wang
Yong-mei Ren
Xiao-yan Chen
Article30 Sept 2024
Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice

Ya-nan Gao
Kai-jun Pan
Jia Li
Article30 Sept 2024
Adaptor protein Src-homology 2 domain containing E (SH2E) deficiency induces heart defect in zebrafish

Yu-lai Liang
Yang-xi Hu
Qing Jing
Article23 Sept 2024
Oral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota

Qin Yang
Wen-hao He
Yu Chen
Article23 Sept 2024
SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating macrophage polarization

Xia-fang Lin
Xiao-na Cui
Tian-pei Hong
ArticleOpen Access18 Sept 2024

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