Acta Pharmacologica Sinica

Structure genomics of SARS-CoV-2 and its Omicron variant

Targeted degradation of membrane and extracellular proteins with LYTACs

Yu-yang Li
Yang Yang
Song-bo Xie

Review Article 05 August 2024

Featured

The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca²⁺ transport in the pathogenesis of diseases

Wen-bin Zhao
Rui Sheng
Review Article08 Aug 2024
Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice

Alejandro Serrano
Noelia Casares
María J. Garrido
ArticleOpen Access29 Jul 2024
A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity

Yin-yan Li
Guo-dong Liang
Jie Yang
Article10 Jul 2024
Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice

Bi-xi Tang
Yong Zhang
Yi Zang
Article05 Aug 2024

Current issue

Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis

Ana Beatriz Santos
Andreia Carona
Joana Bicker
Review Article29 Apr 2024
Insomnia-related rodent models in drug discovery

Ze-ka Chen
Yuan-yuan Liu
Zhi-li Huang
Review Article26 Apr 2024
E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

Chun-yan Duan
Yue Li
Guoqiang Xu
Article13 May 2024
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy

Xiao-lu Jiang
Zu-bin Zhang
Mei Li
Article15 May 2024
Sodium oligomannate activates the enteroendocrine-vagal afferent pathways in APP/PS1 mice

Hua-shan Gong
Jing-pei Pan
Wei-fang Rong
Article03 May 2024
Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E₂ in the lateral parabrachial nucleus of male rats

Jian-hui Xu
Tian-hui He
Jie Zhang
Article03 May 2024

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Announcements

JOIN US | Deputy Director Position of SKLDR

State Key Laboratory of Drug Research (SKLDR), which was approved by Chinese Academy of Sciences under the unremitting efforts of reorganizing the state key laboratory system, is recruiting a Deputy Director. The candidate is expected to help SKLDR to continuously improve the academic influence and the ability to transform new drug achievements into real productivity.

Browse articles

Exploring the constitutive activation mechanism of the class A orphan GPR20

Ming-yang Zhang
Jian-yang Ao
Shao-yong Lu
Article10 Sept 2024
Cardiovascular adverse effects of antiviral therapies for COVID-19: Evidence and plausible mechanisms

Eileen Chen
Lei Xi
Review ArticleOpen Access09 Sept 2024
Artemisinin inhibits neuronal ferroptosis in Alzheimer’s disease models by targeting KEAP1

Peng-xi Deng
Marta Silva
Wen-hua Zheng
Article09 Sept 2024
Palmitoyltransferase ZDHHC3 is essential for the oncogenic activity of PML/RARα in acute promyelocytic leukemia

Xue-jing Shao
Wei Wang
Bo Yang
Article03 Sept 2024
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle

Sha-sha Wang
Ye Peng
Nai-hong Chen
Article03 Sept 2024
Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages

Yi-ping You
Liang Yan
Xian-hui He
Article02 Sept 2024
INHBA promotes tumor growth and induces resistance to PD-L1 blockade by suppressing IFN-γ signaling

Fang-lin Li
Long-hua Gu
Li-kun Gong
Article02 Sept 2024
Preclinical characterization of [¹⁸F]D₂-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates

Kai Liao
Jia-hui Chen
Lu Wang
Article29 Aug 2024
Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer

Zi-yang Liu
Ya-wen Zhang
Xin-liang Mao
Article28 Aug 2024

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LEO Lecturer III in Pharmaceutical Sciences

The College of Pharmacy at the University of Michigan, Ann Arbor, invites applications for a full-time (100%) LEO Lecturer III position in the Depa...

Ann Arbor, Michigan

University of MI- College of Pharmacy
PhD and MSc position at the Faculty of Biology in the Technion - Israel Institute of Technology

Join the Faculty of Biology at the Technion – Israel Institute of Technology The Technion, located in Haifa, Israel, is a world-renowned institutio...

Israel (IL)

Faculty of Biology, Technion
Call for Participation at Forum of Young Scientists Shenzhen University of Advanced Technology

Shenzhen University of Advanced Technology (SUAT) invites interested individuals to its Forum of Young Scientists.

Shenzhen, Guangdong, China

Shenzhen University of Advanced Technology
2024 Recruitment notice Shenzhen Institute of Synthetic Biology: Shenzhen, China

The wide-ranging expertise drawing from technical, engineering or science professions...

Shenzhen,China

Shenzhen Institute of Synthetic Biology
Chief Operating Officer

Salary: £425,000 per annumContract: PermanentClosing date: Sunday 22nd September Founded in 1936, Wellcome is a politically and financially independen

England, London

WellcomeTrust

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

Targeted degradation of membrane and extracellular proteins with LYTACs

Featured

The correlation between mitochondria-associated endoplasmic reticulum membranes (MAMs) and Ca²⁺ transport in the pathogenesis of diseases

Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice

A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity

Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice

Current issue

Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis

Insomnia-related rodent models in drug discovery

E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1

PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy

Sodium oligomannate activates the enteroendocrine-vagal afferent pathways in APP/PS1 mice

Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E₂ in the lateral parabrachial nucleus of male rats

Announcements

JOIN US | Deputy Director Position of SKLDR

Browse articles

Exploring the constitutive activation mechanism of the class A orphan GPR20

Cardiovascular adverse effects of antiviral therapies for COVID-19: Evidence and plausible mechanisms

Artemisinin inhibits neuronal ferroptosis in Alzheimer’s disease models by targeting KEAP1

Palmitoyltransferase ZDHHC3 is essential for the oncogenic activity of PML/RARα in acute promyelocytic leukemia

Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle

Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages

INHBA promotes tumor growth and induces resistance to PD-L1 blockade by suppressing IFN-γ signaling

Preclinical characterization of [¹⁸F]D₂-LW223: an improved metabolically stable PET tracer for imaging the translocator protein 18 kDa (TSPO) in neuroinflammatory rodent models and non-human primates

Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer

Trending - Altmetric

Science jobs

LEO Lecturer III in Pharmaceutical Sciences

PhD and MSc position at the Faculty of Biology in the Technion - Israel Institute of Technology

Call for Participation at Forum of Young Scientists Shenzhen University of Advanced Technology

2024 Recruitment notice Shenzhen Institute of Synthetic Biology: Shenzhen, China

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Organ preservation: from the past to the future

Artemisinin inhibits neuronal ferroptosis in Alzheimer’s disease models by targeting KEAP1

Identification of some benproperine metabolites in humans and investigation of their antitussive effect

Cardiovascular adverse effects of antiviral therapies for COVID-19: Evidence and plausible mechanisms

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