Acta Pharmacologica Sinica

Structure genomics of SARS-CoV-2 and its Omicron variant

Angiogenesis after ischemic stroke

Jie Fang
Zhi Wang
Chao-yu Miao

Review Article 24 February 2023

Featured

Regulated cell death pathways in cardiomyopathy

Shu-yuan Sheng
Jia-min Li
Yibin Wang
Review Article13 Mar 2023
GPR84 regulates pulmonary inflammation by modulating neutrophil functions

Si-wei Wang
Qing Zhang
Xin Xie
ArticleOpen Access04 Apr 2023
Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway

Jing-pei Liang
Yuan-ming He
Xin-liang Mao
Article20 Feb 2023
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription

Yu-fei Wang
Jin-yan Feng
Xiao-dong Zhang
Article24 Feb 2023

Current issue

Dynamic regulation of excitatory and inhibitory synaptic transmission by growth hormone in the developing mouse brain

Guang-ying Li
Qiu-zi Wu
Xiang Yu
Article07 Dec 2022
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson’s disease treatment

Qing Wang
Sheng Yao
Lin-yin Feng
Article10 Jan 2023
Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway

Hong-yang Sun
Jin Wu
Guang-hui Wang
Article19 Dec 2022
Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling

Hao Wu
Lu-xun Tang
Wei Eric Wang
Article06 Dec 2022
SGLT2 inhibitor empagliflozin promotes revascularization in diabetic mouse hindlimb ischemia by inhibiting ferroptosis

Jing-xuan Han
Lai-liu Luo
Shou-rong Wu
Article12 Dec 2022
MANF ameliorates DSS-induced mouse colitis via restricting Ly6C^hiCX3CR1^int macrophage transformation and suppressing CHOP-BATF2 signaling pathway

Lin Yang
Wen-wen Shen
Yu-xian Shen
ArticleOpen Access12 Jan 2023

Contents

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Announcements

JOIN US | Deputy Director Position of SKLDR

State Key Laboratory of Drug Research (SKLDR), which was approved by Chinese Academy of Sciences under the unremitting efforts of reorganizing the state key laboratory system, is recruiting a Deputy Director. The candidate is expected to help SKLDR to continuously improve the academic influence and the ability to transform new drug achievements into real productivity.

Acta Pharmacologica Sinica is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.

Browse articles

β-arrestin2 deficiency ameliorates S-100-induced autoimmune hepatitis in mice by inhibiting infiltration of monocyte-derived macrophage and attenuating hepatocyte apoptosis

Ting-ting Chen
Xiu-qin Li
Wu-yi Sun
Article25 May 2023
Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition

Lei Yu
Ya-fang Wang
Yi Chen
Article25 May 2023
Loss of DJ-1 function contributes to Parkinson’s disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation

Le-le Liu
Yu Han
Hai-gang Ren
Article25 May 2023
Gemcitabine-loaded synthetic high-density lipoprotein preferentially eradicates hepatic monocyte-derived macrophages in mouse liver with colorectal cancer metastases

Feng-qin Xiong
Wen Zhang
Ya-ping Li
Article24 May 2023
FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis

De-pu Zhou
Lian-cheng Deng
Jin-San Zhang
ArticleOpen Access24 May 2023
Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway

Ting-feng Zou
Zhi-gang Liu
Xiao-xiao Yang
Article24 May 2023
Theaflavin mitigates acute gouty peritonitis and septic organ injury in mice by suppressing NLRP3 inflammasome assembly

Si-yuan Chen
Ya-ping Li
Xian-hui He
Article23 May 2023
Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation

Min-chun Jiang
Huan-yu Ding
Yu Huang
Article22 May 2023
COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity

Sai-ya Zhu
Wen-qian Zhou
Chen Yu
Article22 May 2023

Acta Pharmacologica Sinica (APS) proudly celebrates the 90th anniversary of Shanghai Institute of Materia Medica (SIMM). APS summarizes a broad overview of the research progress of SIMM published in our journal in the past decade and provides insight into the exciting and innovative drug research and development in China.

Collection 05 Dec 2022

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Jobs

Staff Scientist Position for a Computational Biologist

seeks to hire a creative and motivated Computational Biology Staff Scientist

Bethesda, Maryland (US)

National Institutes of Health
Postdoctoral Fellow - The Laboratory of Prof. Naoto Hirano

The long-term objective of the Centre for Oncology and Immunology is to identify druggable cancer targets of recalcitrant malignancies and developi...

Hong Kong (HK)

Centre for Oncology and Immunology
2023 Recruitment notice Shenzhen Institute of Synthetic Biology: Shenzhen, China

The wide-ranging expertise drawing from technical, engineering or science professions...

Shenzhen,China

Shenzhen Institute of Synthetic Biology
Tenure-track Assistant Professor in the field of biomedical sciences and metabolism

UNIL is a leading international teaching and research institution, with over 5,000 employees and 15,500 students split between its Dorigny campus, ...

Lausanne, Canton of Vaud (CH)

University of Lausanne (UNIL)
Tenure Track Assistant Professor in Computational Metagenomics and Microbial Modeling

UNIL is a leading international teaching and research institution, with over 5,000 employees and 15,500 students split between its Dorigny campus, ...

Lausanne, Canton of Vaud (CH)

University of Lausanne (UNIL)

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

Angiogenesis after ischemic stroke

Featured

Regulated cell death pathways in cardiomyopathy

GPR84 regulates pulmonary inflammation by modulating neutrophil functions

Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway

Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription

Current issue

Dynamic regulation of excitatory and inhibitory synaptic transmission by growth hormone in the developing mouse brain

Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson’s disease treatment

Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway

Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling

SGLT2 inhibitor empagliflozin promotes revascularization in diabetic mouse hindlimb ischemia by inhibiting ferroptosis

MANF ameliorates DSS-induced mouse colitis via restricting Ly6C^hiCX3CR1^int macrophage transformation and suppressing CHOP-BATF2 signaling pathway

Announcements

JOIN US | Deputy Director Position of SKLDR

Browse articles

β-arrestin2 deficiency ameliorates S-100-induced autoimmune hepatitis in mice by inhibiting infiltration of monocyte-derived macrophage and attenuating hepatocyte apoptosis

Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition

Loss of DJ-1 function contributes to Parkinson’s disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation

Gemcitabine-loaded synthetic high-density lipoprotein preferentially eradicates hepatic monocyte-derived macrophages in mouse liver with colorectal cancer metastases

FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis

Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway

Theaflavin mitigates acute gouty peritonitis and septic organ injury in mice by suppressing NLRP3 inflammasome assembly

Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation

COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity

Collections

Celebrating the 90th Anniversary of SIMM

Trending - Altmetric

Jobs

Staff Scientist Position for a Computational Biologist

Postdoctoral Fellow - The Laboratory of Prof. Naoto Hirano

2023 Recruitment notice Shenzhen Institute of Synthetic Biology: Shenzhen, China

Tenure-track Assistant Professor in the field of biomedical sciences and metabolism

Tenure Track Assistant Professor in Computational Metagenomics and Microbial Modeling

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Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Loss of DJ-1 function contributes to Parkinson’s disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation

Drp1-dependent mitochondrial fission in cardiovascular disease

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