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  • Natural/synthetic hybrid double-network (DN) hydrogels with hierarchical anisotropy and high toughness characteristics are prepared by directly using a squid mantle as an anisotropic soft bioproduct for the primary network and polyacrylamide (PAAm) as a synthetic polymer for the secondary network. The obtained squid/PAAm DN gel maintains the complex orientation of the muscle fibers of the squid mantle and exhibits anisotropic, enhanced mechanical properties and excellent fracture resistance due to its unique composite structure. This hybrid strategy provides a general method for preparing hydrogels with elaborated anisotropy and determining functions derived from the anisotropy.

    • Shou Ohmura
    • Tasuku Nakajima
    • Jian Ping Gong
    Article Open Access
  • Illustration of cellular fate and responses of macrophages to ferritin NPs. With potential theranostic applications of organic NPs targeting macrophages, in-depth study of internalization and cellular responses of a model organic NP (Archaeoglobus fulgidus derived ferritin) is carried out. Multiple pathways for ferritin NP internalization are observed resulting in endosomal/lysosomal localization and intracellular Fe accumulation. Upregulation of endogenous ferritin and iron export protein are noted in response to lysosomal ferritin degradation and release of free Fe ions. Iron-dependent impacts on physiological immune markers and ROS are measured.

    • Samyukta Ravishankar
    • Anu Maashaa Nedumaran
    • Sierin Lim
    Article Open Access
  • In this work, we prepared a composite hydrogel system of PDA-HA hydrogel-loaded CaO2-ICG@LA@MnO2 nanoparticles that showed excellent photothermal performance under NIR irradiation and realized the on-off release of oxygen and ROS. Controllable and sustainable oxygen release can promote the regeneration and repair of damaged tissue, and the generated ROS can effectively inhibit the outbreak of inflammation at the initial stage of wound healing. A full-thickness skin defect repair test was carried out in rats with the prepared hydrogel wound dressings and the results showed that hydrogel + NIR group had the most wound healing effective.

    • Chunyang Li
    • Xiaojun He
    • Deyan He
    Article Open Access
  • We optimized the RL-QN15 peptide to obtain the cyclic heptapeptide (CyRL-QN15) with excellent therapeutic potency against skin wounds. Then, a multifunctional HPDAlCyRL-QN15/ZA hydrogel was prepared and characterized, which significantly enhanced the pro-healing potency of CyRL-QN15. This non-toxic hydrogel accelerated the proliferation, migration, and tube formation of skin cells, regulated the secretion of cytokines, directly scavenged free radicals, and decreased reactive oxygen species. Moreover, the HPDAlCyRL-QN15/ZA hydrogel accelerated the healing of skin wounds in type 2 diabetic mice and diabetic patient skin cultured ex vivo by promoting the polarization of macrophages to reduce inflammation, re-epithelialization, deposition of collagen, and angiogenesis.

    • Zhe Fu
    • Huiling Sun
    • Xinwang Yang
    Article Open Access
  • Natural polyphenols reduce metal ions into metal nanoclusters in water followed by subsequent self-assembly into metal-ornamented polyphenol supramolecular (MOPS) assemblies. MOPS assemblies, which integrate the merits of both the natural polyphenols and metal nanoclusters, possess excellent solubility, stability, and free radical scavenging capacity in aqueous solutions and enable further functional material engineering via polyphenol chemistry.

    • Qiong Dai
    • Tong Shu
    • Xueji Zhang
    Article Open Access
  • A new type of solid-sate colossal barocaloric material was fabricated by exploiting the amorphous high entropy inherited from huge disorder of liquid phase in solidified PEG(HO(CH2CH2O)nH) by introducing 5 wt.% PET((C10H8O4)m) for copolymerization. Although PEG loses –OH end mobility, high entropy still retains in amorphous solid. Consequently, a colossal barocaloric entropy change as high as ΔSp ∼ 416 J·kg1·K1 under a low pressure of 0.1 GPa was demonstrated.

    • Zibing Yu
    • Houbo Zhou
    • Baogen Shen
    Article Open Access
  • Extracellular matrix (ECM) bioscaffolds have been widely studied to repair bladder tissue defects. In this work, ECM bioscaffolds were derived from decellularized sheets and then modified with vascular endothelial growth factor (VEGF)-conjugated superparamagnetic iron oxide nanoparticles to promote angiogenesis. The biomimetic proangiogenic scaffold accelerated vascularization in vivo and promoted urothelium and smooth muscle regeneration. These findings demonstrate that the developed biomimetic proangiogenic scaffold possesses great potential for bladder regeneration applications.

    • Ying Wang
    • Jiasheng Chen
    • Qiang Fu
    Article Open Access
  • Dual-responsive disassembly of core-shell nanoplatform (Au@MPN) is reported with self-supplied H2O2 and autocatalytic Fenton reaction for enhanced chemodynamic therapy. Both ATP and low pH can disassemble the Au@MPN to release Fe(III), which can then be reduced into Fe(II) by the simultaneously released tannic acid. In particular, the exposed gold nanoparticles can catalyze the oxidation of intracellular glucose to produce H2O2. Subsequently, Fe(II) and the self-supplied H2O2 induce an efficient Fenton reaction for chemodynamic therapy by generating hydroxyl radicals. Additionally, tumor growth and melanoma metastatic lung cancer can be effectively suppressed by Au@MPN.

    • Mengran Peng
    • Enguo Ju
    • Mingqiang Li
    Article Open Access
  • In this work, the formation of DNA supramolecular hydrogels was controlled by tuning rigidity of building blocks. The strand displacement reaction was used to in situ tuning the rigidity of the molecular network of the DNA supramolecular hydrogel. Our experiments revealed that the rigidity plays an important role in the formation and mechanical properties of hydrogels.

    • Yufan Pan
    • Bo Yang
    • Dongsheng Liu
    Article Open Access
  • Tuning of the oscillations within a single nanodevice is a vital factor for harnessing them to neuromorphic computing. Herein, tuning of the oscillation properties of spin structures within a single permalloy circular disk achieved by manipulating the dimensionality of spin structures is directly observed by the time-resolved X-ray microscopy.

    • Hee-Sung Han
    • Sooseok Lee
    • Ki‐Suk Lee
    Article Open Access
  • The wafer-scale homogeneous growth of WS2xSe2(1-x) monolayer alloys with full-range composition and bandgap modulation is demonstrated using metal–organic chemical vapor deposition. In these 2D TMD alloys, the bowing effect is substantially alleviated, enabling systematic bandgap modulation with the linear relationship between optical bandgap and alloying composition.

    • Hee Seong Kang
    • Jung Hoon Kang
    • Chul-Ho Lee
    Article Open Access
  • We developed all-solution-processed broadband photodetectors based on the wafer-scale perovskite quantum dots (PQDs)/MoS2 through light management via the monochromatization effect of the PQDs. The rational nanohybrid-based photodetectors exhibited broadband photodetection behavior that retained high photocurrents over a wide spectral range and also show superb air stability and exceptional bending durability.

    • Minji Kim
    • Garam Bae
    • Sun Sook Lee
    Article Open Access
  • In this study, we prepared OKPP hydrogel constructed from, OKGM, ε-PL, and γ-PGA modified by dopamine and l-cysteine. OKPP hydrogel has the ability of injectable and self-healing through the thiol-aldehyde addition and schiff-base reactions, which can solve the problem of long time use and gel breaking. OKPP hydrogel has antioxidant properties and can scavenge free radicals. This hydrogel has good antibacterial effect on Pseudomonas aeruginosa and Staphylococcus aureus, and also has strong adhesion. In the burn wound infection model, OKPP hydrogel can promote wound healing and reduce the production of inflammatory factors. It is proved that this hydrogel has good clinical potential as a wound dressing for burn wound infection.

    • Ao Sun
    • Danrong Hu
    • Zhiyong Qian
    Article Open Access
  • A facile chemical vapor method is developed for large-scale synthesis of CsPbX3-ZSM-5 composites. Owing to the effective confinement and encapsulation of CsPbBr3 QDs by ZSM-5, the composites possess excellent photophysical properties and ultrahigh stability. The prepared composites are applied in white light-emitting diodes (WLEDs) and multicolor-coded anti-counterfeiting inks. This technique provides the probability for commercial production of these perovskite composites with robust stability.

    • Tongyu Shi
    • Xi Chen
    • Xue-Feng Yu
    Article Open Access
  • A magnetic superhydrophobic tubular actuator for water transport has been designed and successfully demonstrated. Under the control of an externally applied magnetic field, the actuator could deform correspondingly and propel the water droplet in the tube to move forward with a high speed up to 16.1 cm/s, which is the highest velocity measured for water transport in a closed actuator system. Several representative liquids (i.e., phosphate buffer solution, artificial urine, and sweat) widely used in biomedical engineering have also been achieved to transport in the tubular actuator with negligible liquid loss under an applied magnetic field.

    • Fangyihan Xiong
    • Liyun Zhang
    • Fan Xia
    Article Open Access
  • A very active research area in superconductivity is the performance improvementofthe current carrying capability (Jc). Here, we show that the depairing current (Jd) can beincreased by controlling the penetration depth (λ) and coherence length (ξ) in the two most representative materials: in REBa2Cu3Oy we increased the carrier density to decrease λ and ξ, and in BaFe2(As1-xPx)2 we tuned the chemical pressure. The combination ofthese thermodynamic and flux-pinning optimization routes leads to a dramatic increase of Jc to Jc ~150 MA/cm2 at 4.2 K (32.4% of Jd) for REBa2Cu3Oy, the highest value ever reported for any superconductor.

    • Masashi Miura
    • Go Tsuchiya
    • Boris Maiorov
    Article Open Access