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Dual-responsive disassembly of core-shell nanoparticles with self-supplied H2O2 and autocatalytic Fenton reaction for enhanced chemodynamic therapy

Authors report a core-shell nanoplatform with dual-responsive disassembly that self-supplies H2O2 and undergoes an autocatalytic Fenton reaction for enhanced chemodynamic therapy.

  • Mengran Peng
  • Enguo Ju
  • Mingqiang Li
Article

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    SPECIAL ISSUE | Hydrogels are of great interests from the viewpoints of their diverse applications such as disposal water absorbent, tissue engineering, drug delivery, etc. New synthetic techniques as well as analytical methods have opened new gates to intelligent and advanced hydrogel-related materials.

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    • Jiasheng Chen
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  • Dual-responsive disassembly of core-shell nanoplatform (Au@MPN) is reported with self-supplied H2O2 and autocatalytic Fenton reaction for enhanced chemodynamic therapy. Both ATP and low pH can disassemble the Au@MPN to release Fe(III), which can then be reduced into Fe(II) by the simultaneously released tannic acid. In particular, the exposed gold nanoparticles can catalyze the oxidation of intracellular glucose to produce H2O2. Subsequently, Fe(II) and the self-supplied H2O2 induce an efficient Fenton reaction for chemodynamic therapy by generating hydroxyl radicals. Additionally, tumor growth and melanoma metastatic lung cancer can be effectively suppressed by Au@MPN.

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    • Enguo Ju
    • Mingqiang Li
    Article Open Access
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Special issue on Hydrogels and Hydrogel-related Healing Materials

Special issue on Hydrogels and Hydrogel-related Healing Materials

Hydrogels are of great interests from the viewpoints of their diverse applications such as disposal water adsorbent, tissue engineering, drug delivery, etc. New synthetic techniques as well as analytical methods have opened new gates to intelligent and advanced hydrogel-related materials. In combination with the broad term “healing”, the hydrogel-related materials have also been experiencing remarkable innovations. Some of the healing materials are designed for their own repair, others to assist the healing of the damaged bio-organisms. This special issue of NPG Asia Materials is focusing on the recent innovations related to hydrogels and hydrogel-related healing material, and presents state-of-the-art original articles as well as comprehensive reviews in this fast-growing field.
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