Hydrogels are of great interests from the viewpoints of their diverse applications such as disposal water adsorbent, tissue engineering, drug delivery, etc. New synthetic techniques as well as analytical methods have opened new gates to intelligent and advanced hydrogel-related materials. In combination with the broad term “healing”, the hydrogel-related materials have also been experiencing remarkable innovations. Some of the healing materials are designed for their own repair, others to assist the healing of the damaged bio-organisms. This special issue of NPG Asia Materials is focusing on the recent innovations related to hydrogels and hydrogel-related healing material, and presents state-of-the-art original articles as well as comprehensive reviews in this fast-growing field.