
The human brain’s characteristic wrinkles help to drive how it works
A model of the brain’s geometry better explains neuronal activity than a model based on the ‘connectome’.
A model of the brain’s geometry better explains neuronal activity than a model based on the ‘connectome’.
An explosion of skeletal editing methods to insert, delete or swap individual atoms in molecular backbones could accelerate drug discovery.
Brain activity is structured in space and time. The resulting activity patterns are conventionally thought to depend on an intricate web of anatomical connections that link specialized populations of cells. This work challenges this paradigm by showing that macroscale neuronal dynamics of the human brain are fundamentally shaped by its physical geometry.