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| Open AccessIron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention
Ferumoxytol (Fer) is an FDA-approved iron oxide formulation that disrupts caries-causing biofilms with high specificity but cannot interfere with enamel acid demineralization. Here, Fer is combined with stannous fluoride (SnF2), resulting in enhanced stability of SnF2 and inhibition of both biofilm accumulation and enamel damage more effectively than either alone.
- Yue Huang
- , Yuan Liu
- & Hyun Koo
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Article
| Open AccessStructural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants
EDA variants are associated with X-linked hypohidrotic dysplasia. Here, the authors report the crystal structure of the human EDA-EDAR complex, reveal the important role of this complex in ectodermal development and uncover the structural mechanism of disease-related mutations in EDA.
- Kang Yu
- , Chenhui Huang
- & Yiqun Wu
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Article
| Open AccessAn umbrella review of the evidence linking oral health and systemic noncommunicable diseases
Previous studies have supported a potential bidirectional association between oral diseases and systemic noncommunicable diseases (NCDs) Here the authors perform an umbrella review of meta-analyses for the association between oral health and NCDs, and report that 27 NCDs were associated with oral disease, however, the overall strength of evidence was found to be unfavorable and with methodological inconsistencies.
- João Botelho
- , Paulo Mascarenhas
- & Vanessa Machado
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Article
| Open AccessTopical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity
Ferumoxytol is a nanoparticle formulation approved for systemic use to treat iron deficiency. Liu et al. show that topical use of ferumoxytol, in combination with low concentrations of H2O2, disrupts intractable oral biofilms and prevents tooth decay in vitro and in an animal model.
- Yuan Liu
- , Pratap C. Naha
- & Hyun Koo