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Bone is a mineralized connective tissue from which bones, the main component of the vertebrate skeleton, are formed. Bone tissue is composed of cells, namely osteoblasts, osteoclasts and osteocytes, and an extracellular matrix comprising inorganic hydroxyapatite crystals and organic collagen.
Results of a new study indicate that eosinophils have a role in maintaining bone homeostasis through their inhibitory effects on bone-resorbing osteoclasts.
New research shows that deficiency of the sulfation-related SLC26A2 affects osteocyte formation, and that targeting downstream mediators can ameliorate SLC26A2-deficient osteoporosis.
New findings suggest that neutrophil extracellular traps and their components have a functional role as triggers of IL-17-mediated inflammation and associated bone destruction in periodontitis.
Researchers have co-cultured human mesenchymal stromal cells and monocytes to generate bone-like structures that have the potential to facilitate the study of bone remodelling in vitro.