Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Pathologic α-synuclein spreads from cell-to-cell through binding to the lymphocyteactivation gene 3 (Lag3). Here, the authors demonstrate that the amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 and facilitates the binding, internalization, transmission, and toxicity of pathologic α-synuclein.
There is a lack of vaccines for prevention of human respirovirus 3 (RV3) infection. Bakkers et al. report the design of a stabilized RV3 preF protein vaccine candidate that induces strong neutralizing antibodies and protective responses in small animal models.
Biaryl compounds with an axial chirality are valuable architectures but few methods have been developed for the construction of bridged biaryls, a subclass of these compounds that bear a tether to connect the two arenes and form a medium-sized ring. Here, the authors design a Co/SPDO-catalyzed aerobic oxidative coupling/desymmetrization sequence of prochiral phenols for the enantioselective synthesis of biaxial bridged m-terphenyls embedded in an azocane.
The 2021 Pacific Northwest Heatwave challenged standard attribution methods. The authors use a weather model that predicted the event to quantify human impact on the heat, suggesting that such models could be used broadly to assess changing weather risk.
African swine fever virus is the sole mammalian-infecting virus encoding a type II topoisomerases (pP1192R). The authors present pP1192R structures in different states, illustrating the enzymatic mechanisms of viral type II topoisomerases.
A comprehensive understanding of the transient characteristics in solid oxide cells is crucial when integrated with intermittent renewable energy. Here, authors reveal expressions for two general characteristic times quantifying transient phenomena due to heat and mass transfer lags in SOCs.
Human HtrA2 plays an important part in the cellular protein quality control system. Here, advanced NMR spectroscopy unravels the initial activation steps of HtrA2 upon activating peptide binding and the mechanistic role of divalent cations.
The tuning properties of ventral stream neurons for object shape and category are not fully understood. Here the authors carry out multi-electrode array recordings in lateral occcipital complex and find that object properties are largely shape-based.
Frequent chromosome fusion and fission in oomycetes drive changes in chromosome number. Here, Zhang et al show that these dynamics facilitate the adaptive evolution of genes related to pathogenicity.
Replication stress induces STING-TRPV2 dissociation to promote Ca2+ release from the ER for fork protection; however, the precise mechanism remains unclear. Here, the authors identify TCAF1 as a fork protection factor that facilitates STING-TRPV2 dissociation, thereby enabling Ca2+ release.
Dbr1 exhibits debranching specificity and effect on splicing. Here the authors combine co-immunoprecipitation, RNA binding and lariat analysis and suggest a role for Dbr1 interactor AQR in intron recycling. Dbr1 depletion leads to increased dwell time of spliceosome on excised lariats.
The paralogous NLR proteins, Pit1 and Pit2, exhibit distinct functions in rice immunity, where Pit1 induces cell death on the plasma membrane and Pit2 inhibits this function by sequestering Pit1 to the cytosol.
Nanobodies are promising GPCR-targeting therapeutics. Here, the authors investigate a nanobody targeting atypical chemokine receptor 3 (ACKR3), and map trends in GPCR nanobody structure, mechanism, and selectivity.
Mosquito biting preferences and their impact on malaria transmission are not well understood. Here, the authors report findings from a longitudinal cohort study in Western Kenya which show that males aged 5-15 years tend to be bitten the most, and infectious mosquitoes appear to be more likely to bite infected individuals.
Ancestral environments can induce heritable phenotypic changes, but whether it is a common phenomenon remains unknown. This long-term experiment in Arabidopsis thaliana reveals that environment-induced heritable changes that are common, reproducible, and predictable.
In Arabidopsis, the pollen vegetative cell is regarded as a source of mobile siRNAs that guide male germline reprogramming. This study demonstrates that siRNA triggers of triploid seed lethality originate in germline companion cells after meiosis.
Interleukin-33 (IL-33) is a master initiator of cancer-prone chronic inflammation. Here, the authors show that TLR3/4-TBK1-IRF3 pathway activation induces IL-33, and the cholesterol-lowering drug, statin, blocks this pathway to suppress chronic inflammation and its cancer sequela.
Producing valuable chemicals like ethylene via catalytic CO conversion is an important nonpetroleum route. Here, authors demonstrate high-rate electrosynthesis of multicarbon chemicals via CO electrolysis, with a multicarbon product partial current density of 4.35 A cm−2 at a cell voltage of 2.78 V.
A radiation damage cycle in X-ray-ionized solvated Mg ions is reported by the authors leading to production of water radicals and low-energy electrons. The Mg ion ends in its initial state quickly and can restart the cycle, multiplying the local damage.
Sepsis is a global challenge and a significant burden in Sub-Saharan Africa. Here, Chenoweth et al profile host gene expression signatures from a cohort in Ghana to define molecular phenotypes and identify potential targets to improve patient outcomes.