Branch point selection is required for pre-mRNA splicing, and its mis-regulation is associated with many diseases. Two structural studies provide insights into the dynamics of active site formation and the spliceosomal proteins that may contribute to activation of the correct branch point in eukaryotic introns.
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Acknowledgements
This work was funded by National Institutes of Health (NIH) grants R01GM098634 and R01GM140082 (to J.A.P.).
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Downs, S.R., Grace, B. & Pleiss, J.A. Decoding branch points and unlocking splicing secrets. Nat Struct Mol Biol 31, 732–734 (2024). https://doi.org/10.1038/s41594-024-01308-4
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DOI: https://doi.org/10.1038/s41594-024-01308-4