Clinical trial data suggest that thiazides and thiazide-like drugs could be beneficial for blood-pressure lowering in patients with severe chronic kidney disease. However, prolonged exposure to these photosensitizing drugs could translate into increased risk of squamous cell carcinoma and post-transplant diabetes in the already extremely vulnerable kidney transplant population.
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Van Laecke, S. Thiazides in kidney transplant recipients: skin in the game. Nat Rev Nephrol 20, 351–352 (2024). https://doi.org/10.1038/s41581-024-00839-9
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DOI: https://doi.org/10.1038/s41581-024-00839-9