Article
|
Open Access
Featured
-
-
Article
| Open AccessA cluster-randomized trial of water, sanitation, handwashing and nutritional interventions on stress and epigenetic programming
A regulated stress response is essential for healthy child growth and development. Here, the authors show that a nutrition, water, sanitation, and hygiene intervention enhanced adaptive responses of the physiological stress system in early childhood.
- Audrie Lin
- , Andrew N. Mertens
- & Douglas A. Granger
-
Article
| Open AccessA midbrain GABAergic circuit constrains wakefulness in a mouse model of stress
Neural circuit mechanisms underlying prevention of hyperarousal in acute stress conditions are not fully understood. Here authors show GAD2-positive GABAergic neurons in the midbrain dorsal raphe nucleus constrain the increase of wakefulness to prevent hyperarousal in a mouse model of stress.
- Shuancheng Ren
- , Cai Zhang
- & Zhian Hu
-
Article
| Open AccessReplication study on the role of dopamine-dependent prefrontal reactivations in human extinction memory retrieval
Dopamine may help strengthen fear-inhibitory extinction memories through influences on the prefrontal cortex. Here, the authors replicate their previous finding that prefrontal reactivations are predictive of extinction memory retrieval but do not replicate the enhancing effects of L-DOPA.
- Elena Andres
- , Hu Chuan-Peng
- & Raffael Kalisch
-
Article
| Open AccessNuclei-specific hypothalamus networks predict a dimensional marker of stress in humans
The association between connectivity of the hypothalamus and stress is not well understood. Here, the authors show connectivity between hypothalamic nuclei and other subcortical structures is predictive of stress.
- Daria E. A. Jensen
- , Klaus P. Ebmeier
- & Miriam C. Klein-Flügge
-
Article
| Open AccessPrefrontal control of superior colliculus modulates innate escape behavior following adversity
Significant aversive experience can cause lasting behavioral changes due to shifts in arousal thresholds and filter mechanisms. Here, in male mice, the authors identify a change in a neural circuit, underlying adversity driven enhanced threat response.
- Ami Ritter
- , Shlomi Habusha
- & Oded Klavir
-
Article
| Open AccessMicroglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice
Stress-related anxiety can gradually become extinct but the underlying mechanisms are unclear. Here, the authors show that microglial engulfment of dendritic spines promotes the extinction of acute stress-induced anxiety-like behaviors in mice.
- Danyang Chen
- , Qianqian Lou
- & Yan Jin
-
Article
| Open AccessStress-induced vagal activity influences anxiety-relevant prefrontal and amygdala neuronal oscillations in male mice
Interactions between the brain and the vagus nerve is crucial for expressing emotions. Here, authors show that vagus nerve activity is associated with prefrontal-amygdalar oscillations and restores stress-induced behavior.
- Toya Okonogi
- , Nahoko Kuga
- & Takuya Sasaki
-
Article
| Open AccessHypothalamic CRH neurons represent physiological memory of positive and negative experience
How physiological memories are encoded is not fully understood. Here the authors show how physiological memories of aversive and appetitive experience are represented by corticotropin-releasing hormone synthesizing neurons in the paraventricular nucleus of the hypothalamus and demonstrate that behavioral readouts may not accurately reflect physiological changes invoked by the memory of salient experiences.
- Tamás Füzesi
- , Neilen P. Rasiah
- & Jaideep S. Bains
-
Article
| Open AccessThe claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology
The stress etiology of depression remains elusive. Here, authors show that dynorphin/KOR signaling-mediated impairment of excitatory synaptic transmission from claustrum to prelimbic cortex PV interneurons contributes to stress-induced depression.
- Yu-Jun Wang
- , Gui-Ying Zan
- & Jing-Gen Liu
-
Article
| Open AccessStress-induced red nucleus attenuation induces anxiety-like behavior and lymph node CCL5 secretion
Exposure to stressors can trigger or exacerbate anxiety through an inflammatory response. Here, the authors demonstrate the function of a “brain-lymph node” axis in anxiety and provide insights into lymph nodes as stress-responsive endocrine organs.
- Dong-Dong Shi
- , Ying-Dan Zhang
- & Zhen Wang
-
Article
| Open AccessVentral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice
Ventral striatal Islands of Calleja neurons, known to regulate grooming in mice, are reported to bidirectionally mediate depression-like behaviors. Here, authors link grooming, dopamine signaling and affective behaviors via ventral striatal circuits.
- Yun-Feng Zhang
- , Jialiang Wu
- & Minghong Ma
-
Article
| Open AccessAutomatically annotated motion tracking identifies a distinct social behavioral profile following chronic social defeat stress
Accurate phenotyping is key to deciphering behavior. Here, authors show the utility of the software package DeepOF in supervised and unsupervised identification of distinct individual and social behavioral patterns following chronic social stress.
- Joeri Bordes
- , Lucas Miranda
- & Mathias V. Schmidt
-
Article
| Open AccessNeutrophil-derived catecholamines mediate negative stress effects on bone
Authors present both preclinical data in mice and clinical data from humans in support of the hypothesis that stress negatively affects bone growth and repair. These effects are mediated by neutrophil-derived catecholamines inhibiting cartilage-to-bone transition via β2-adrenoceptor signaling in chondrocytes.
- Miriam E. A. Tschaffon-Müller
- , Elena Kempter
- & Stefan O. Reber
-
Article
| Open AccessState-level macro-economic factors moderate the association of low income with brain structure and mental health in U.S. children
Lower income is associated with smaller hippocampal volume and mental health problems. Here, the authors show that this association is weaker in areas of the United States that are less expensive or that have a stronger social safety net.
- David G. Weissman
- , Mark L. Hatzenbuehler
- & Katie A. McLaughlin
-
Article
| Open AccessRegulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships
Here, the authors identify a frontostriatal circuit that is involved in regulating social interactions based on learned hierarchical relationships.
- Robert N. Fetcho
- , Baila S. Hall
- & Conor Liston
-
Article
| Open AccessNeural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice
Effective stress regulation is essential for the survival of vertebrates. Here, the authors show that the lateral habenula trace aminergic signalling activates the mesolimbic pathway through suppressing the rostromedial tegmental nucleus to manage stress.
- Soo Hyun Yang
- , Esther Yang
- & Hyun Kim
-
Article
| Open AccessA computational analysis of mouse behavior in the sucrose preference test
The sucrose preference test is one of the most widely used paradigms in behavioral neuroscience. Here, authors identify previously unrecognized behavioral subcomponents that can influence how it is interpreted.
- Jeroen P. H. Verharen
- , Johannes W. de Jong
- & Stephan Lammel
-
Article
| Open AccessHippocampal sharp wave ripples underlie stress susceptibility in male mice
Stressful memories are a possible factor to induce psychiatric symptoms. Here, the authors demonstrate that stress susceptibility is related to memory consolidation mechanisms in the ventral hippocampus.
- Nahoko Kuga
- , Ryota Nakayama
- & Takuya Sasaki
-
Article
| Open AccessThe estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling
Early-life adversity (ELA) can lead to anxiety disorders, which are more prevalent and debilitating in women than men. Here, authors reveal how ELA interacts with neurosteroid synthesis in the hippocampus to drive avoidance behavior in female mice.
- Blake J. Laham
- , Sahana S. Murthy
- & Elizabeth Gould
-
Comment
| Open AccessLeveraging the science of stress to promote resilience and optimize mental health interventions during adolescence
Adolescence is marked by heightened stress exposure and psychopathology, but also vast potential for opportunity. We highlight how researchers can leverage both developmental and individual differences in stress responding and corticolimbic circuitry to optimize interventions during this unique developmental period.
- Dylan G. Gee
- , Lucinda M. Sisk
- & Nessa V. Bryce
-
Article
| Open AccessMettl3-dependent m6A modification attenuates the brain stress response in Drosophila
The brain is vulnerable to stress and disease, with much work focused on defining mechanisms that impact the brain’s resilience. Here the author’s reveal in Drosophila that m6A epitranscriptomic modification of RNA dampens the brain’s capacity to mitigate stress by regulating RNA stability and translation.
- Alexandra E. Perlegos
- , Emily J. Shields
- & Nancy M. Bonini
-
Article
| Open AccessA functional role of meningeal lymphatics in sex difference of stress susceptibility in mice
The mechanisms underlying sex differences in response to stress are unclear. Here, the authors show that meningeal lymphatics dysfunction modulates the sex difference in the stress susceptibility to depression- and anxiety-like behaviours in mice.
- Weiping Dai
- , Mengqian Yang
- & Xiaojing Ye
-
Article
| Open AccessSerotonin and dopamine modulate aging in response to food odor and availability
This report finds that dietary restriction, the most extensively studied anti-aging intervention, can be mimicked by blocking food odour signaling and identifies a neural network of food perception that functions through serotonin and dopamine.
- Hillary A. Miller
- , Shijiao Huang
- & Scott F. Leiser
-
Article
| Open AccessSocial isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish
Social interactions are known to guide behaviour, but how different species represent social stimuli is poorly understood. In this study, the authors demonstrate how social cues in the larval zebrafish suppress an oxytocinergic circuit, which regulates avoidance and feeding behaviour.
- Caroline L. Wee
- , Erin Song
- & Samuel Kunes
-
Article
| Open AccessMultiomic profiling of the acute stress response in the mouse hippocampus
Acute stress can help individuals to respond to challenging events, although chronic stress leads to maladaptive changes. Here, the authors present a multi omic analysis profiling acute stress-induced changes in the mouse hippocampus, providing a resource for the scientific community.
- Lukas M. von Ziegler
- , Amalia Floriou-Servou
- & Johannes Bohacek
-
Article
| Open AccessSWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress
Repeated exposure to social stressors in rodents results in behavioural changes. Here the authors show that behavioural adaptations to stress are associated with nuclear organization changes through SWI/SNF chromatin remodeler in specific neuronal populations of the mesolimbic system.
- Abdallah Zayed
- , Camille Baranowski
- & Sébastien Parnaudeau
-
Article
| Open AccessPercolation in networks with local homeostatic plasticity
Link damages and failures can break the functionality of the whole complex network. Inspired by biological systems that respond to damages, the authors propose a mathematical model revealing the effect of homeostatic response to damage of links to keep the network’s global function.
- Giacomo Rapisardi
- , Ivan Kryven
- & Alex Arenas
-
Article
| Open AccessVascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue
The vascular, cellular and molecular changes underlying sex differences in mood disorders are unclear. Here, the authors show that blood-brain barrier dysfunction modulates anxiety- and depressive-like behaviors in female mice and endothelium-specific changes associated with maladaptive responses compared to resilience to stress.
- Laurence Dion-Albert
- , Alice Cadoret
- & Caroline Menard
-
Article
| Open AccessNeuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice
The mechanisms underlying the chronic stress-induced increased risk for major depressive disorder and anxiety are unclear. Here, the authors show the transcriptional changes occurring in neocortical neurons and identify YY1 as a regulator of chronic stress-induced maladaptive behavior in mice.
- Deborah Y. Kwon
- , Bing Xu
- & Zhaolan Zhou
-
Article
| Open AccessRepeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice
Chronic stress induces maladaptive changes in the neural networks and it’s associated with mood disorders. Here, the authors show that repeated exposure to short-term stress can resolve pre-existing chronic stress induced depressive-like behaviour in mice.
- Eun-Hwa Lee
- , Jin-Young Park
- & Pyung-Lim Han
-
Article
| Open AccessCircadian neurons in the paraventricular nucleus entrain and sustain daily rhythms in glucocorticoids
It is unclear how circadian signals from the suprachiasmatic nucleus (SCN) are decoded to generate daily rhythms in hormone release. Here, the authors show that daily corticosterone release depends on coordinated clock gene and neuronal activity rhythms in both SCN and paraventricular nucleus neurons.
- Jeff R. Jones
- , Sneha Chaturvedi
- & Erik D. Herzog
-
Article
| Open AccessDistinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors
Glucocorticoid hormones (GCs) are of critical importance for maintaining brain health, but their involvement in mental disorders is poorly understood. Here the authors show how GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to impact the gene regulatory programs underpinning neuronal plasticity, ciliogenesis and behavioral adaptation.
- Karen R. Mifsud
- , Clare L. M. Kennedy
- & Johannes M. H. M. Reul
-
Article
| Open AccessStress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor processing and potentially altering adult synaptic plasticity.
- Silvia Martinelli
- , Elmira A. Anderzhanova
- & Nils C. Gassen
-
Article
| Open AccessDelineation of an insula-BNST circuit engaged by struggling behavior that regulates avoidance in mice
Active responses to stressors involve motor planning, execution, and feedback. The authors identify a neuronal projection from the insular cortex to the bed nucleus of the stria terminalis that is activated during motor struggling in response to restraint stress as a potential active coping response.
- Joseph R. Luchsinger
- , Tracy L. Fetterly
- & Samuel W. Centanni
-
Article
| Open AccessVentral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice
Acute stress transiently disrupts reward-seeking behaviour and repeated stress exposure produces lasting anhedonia-like behaviour in rodents. Here, the authors show that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-seeking behaviour in mice.
- Daniel C. Lowes
- , Linda A. Chamberlin
- & Alexander Z. Harris
-
Article
| Open AccessReduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression
Stress is a major risk for mental illness that is known to impact glutamate function in the medial prefrontal cortex (mPFC). Using magnetic resonance spectroscopy we find evidence for an adaptive mPFC glutamate response to stress in healthy adults that is notably impaired in patients with major depression.
- Jessica A. Cooper
- , Makiah R. Nuutinen
- & Michael T. Treadway
-
Article
| Open AccessReal-world stress resilience is associated with the responsivity of the locus coeruleus
Individuals vary considerably in how they are affected by stress. Here, the authors show that the severity of psychopathological symptoms triggered by prolonged real-life stress relate to fMRI-measured responsivity of the human brainstem arousal system and associated pupil responses.
- Marcus Grueschow
- , Nico Stenz
- & Birgit Kleim
-
Article
| Open AccessCellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification
Neural stem and progenitor cells (NSPCs) encounter constant stresses during aging, such as elevated oxidative stress. Here the authors show that oxidative stress induced reduction in NSPC neural differentiation is mediated by a FOXO3-GNMT/SAM-lamin-cGAS/STING-IFN-I signalling cascade initiated by FOXO3 oxidation.
- Inah Hwang
- , Hiroki Uchida
- & Jihye Paik
-
Article
| Open AccessEffect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system
The gut microbiota may contribute to depression, but the underlying mechanism is not well understood. Here the authors use a mouse model of stress induced depression to demonstrate that behavioural changes conferred by fecal transplant from stressed to naïve mice require the endocannabinoid system.
- Grégoire Chevalier
- , Eleni Siopi
- & Pierre-Marie Lledo
-
Article
| Open AccessTactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis
Touch can positively modulate cognitive performance and emotional response. Here the authors demonstrate that enriched tactile experience improves memory and reduces anxiety in adult mice by remodelling the pathway from the primary somatosensory cortex to the dentate gyrus.
- Chi Wang
- , Hui Liu
- & Xiao-Dong Wang
-
Article
| Open AccessOver-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat
Alexander et al. causally implicate over-activity in primate subgenual cingulate in affective and cardiovascular dysfunction relevant to anxiety and depression. Over-activation led to elevated activity in a stress-related network whilst decreasing activity in higher-order prefrontal cognitive regions.
- Laith Alexander
- , Christian M. Wood
- & Angela C. Roberts
-
Article
| Open AccessA discrete serotonergic circuit regulates vulnerability to social stress
Serotonin is important in depression-like behavior. Here the authors show that dorsal raphe neurons that project to the ventral tegmental area are involved in regulating stress responses in mice.
- Wen-Jun Zou
- , Yun-Long Song
- & Tian-Ming Gao
-
Article
| Open AccessPreventing and treating PTSD-like memory by trauma contextualization
Individuals with PTSD are unable to recollect contextual cues related to the trauma. Here the authors show that this contextual amnesia, associated with the inhibition of hippocampal activity, is causally involved in PTSD-like hypermnesia in mice, and that re-exposure to all trauma-related cues eliminates PTSD-like memory while promoting normal fear memory.
- Alice Shaam Al Abed
- , Eva-Gunnel Ducourneau
- & Aline Desmedt
-
Article
| Open AccessHippocampal seed connectome-based modeling predicts the feeling of stress
Although the feeling of being stressed is ubiquitous and clinically significant, the underlying neural mechanisms are unclear. Using a novel predictive modeling approach, the authors show that functional hippocampal networks specifically and consistently predict the feeling of stress.
- Elizabeth V. Goldfarb
- , Monica D. Rosenberg
- & Rajita Sinha
-
Article
| Open AccessPTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
Neuroinflammation has been proposed to accompany the peripheral inflammation observed in PTSD. Here, authors find lower in vivo and postmortem levels of neuroimmune marker TSPO (translocator protein) in PTSD, in association with greater PTSD severity and higher plasma CRP.
- Shivani Bhatt
- , Ansel T. Hillmer
- & Kelly P. Cosgrove
-
Article
| Open AccessA limbic circuitry involved in emotional stress-induced grooming
Self-grooming is a frequently observed repetitive behaviour in rodents that is believed to contribute to post-stress de-arousal. The authors identified a previously unknown limbic circuit that includes the ventral lateral septum in rats and is involved in regulating stress-induced self-grooming.
- Ming-Dao Mu
- , Hong-Yan Geng
- & Ya Ke
-
Article
| Open AccessStress gates an astrocytic energy reservoir to impair synaptic plasticity
Enduring changes in synaptic efficacy are highly sensitive to stress. Here, the authors show that astrocytic delivery of metabolites has an important role in the stress-mediated impairment of synaptic plasticity.
- Ciaran Murphy-Royal
- , April D. Johnston
- & Grant R. Gordon
-
Article
| Open AccessA double-hit of stress and low-grade inflammation on functional brain network mediates posttraumatic stress symptoms
Low-grade systemic inflammation and stress increase vulnerability to neuropsychiatric disorders. Here, the authors show that inflammation and stress-induced changes in higher order cognitive networks increase vulnerability to posttraumatic stress disorder.
- Jungyoon Kim
- , Sujung Yoon
- & In Kyoon Lyoo
-
Article
| Open AccessAdverse caregiving in infancy blunts neural processing of the mother
The roots of psychopathology take shape during adverse parent-infant interactions, shown through infant attachment quality. Using rodents, the authors show that blunted infant cortical processing of the mother determines attachment quality through a stress hormone-dependent mechanism.
- Maya Opendak
- , Emma Theisen
- & Regina M. Sullivan