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We present a method to alleviate re-identification risks behind sharing haplotype reference panels for imputation. In an anonymized reference panel, one might try to infer the genomes’ phenotypes to re-identify their owner. Our method protects against such attack by shuffling the reference panels genomes while maintaining imputation accuracy.
Multicellular modeling is increasingly being used to understand biological systems. SimuCell3D is a tool that allows mechanically realistic simulations, using the deformable cell model, to be developed and run.
Wastewater surveillance has the potential to be used for early detection of new SARS-CoV-2 lineages. Here, the authors present Crykey, a computational method for detecting cryptic SARS-CoV-2 mutations in wastewater that co-occur on the same sequencing read, potentially representing new lineages.
The authors develop a web resource to present pan-cancer mutations in 32 major types of cancer. This new online somatic mutations atlas, OncoDB is publicly available at https://oncodb.org.
We present a method to alleviate re-identification risks behind sharing haplotype reference panels for imputation. In an anonymized reference panel, one might try to infer the genomes’ phenotypes to re-identify their owner. Our method protects against such attack by shuffling the reference panels genomes while maintaining imputation accuracy.
In this Tools of the Trade article, Vipul Singhal and Nigel Chou describe BANKSY, a machine learning tool that harnesses gene expression gradients from the neighbourhood of a cell for cell typing and domain segmentation.
Multicellular modeling is increasingly being used to understand biological systems. SimuCell3D is a tool that allows mechanically realistic simulations, using the deformable cell model, to be developed and run.