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| Open AccessGenomic and panproteomic analysis of the development of infant immune responses to antigenically-diverse pneumococci
By combining genome sequencing and antibody binding (to all common pneumococcal proteins) data, Croucher et al. present a high-resolution analysis of the emergence of immune responses in children that can protect against pneumonia.
- Nicholas J. Croucher
- , Joseph J. Campo
- & David Goldblatt
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| Open AccessMolecular fingerprints resolve affinities of Rhynie chert organic fossils
It can be challenging to identify extinct organisms with morphology alone. Here, the authors use non-destructive Fourier Transform Infrared Spectroscopy to determine the molecular fingerprints of eukaryotes and prokaryotes from the 407 Ma Rhynie chert fossil assemblage of Aberdeenshire, Scotland.
- C. C. Loron
- , E. Rodriguez Dzul
- & S. McMahon
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| Open AccessCvkR is a MerR-type transcriptional repressor of class 2 type V-K CRISPR-associated transposase systems
RNA-guided, CRISPR-associated transposons hold great promise for precision genome editing. Here, the authors provide genetic, biochemical and structural data how their activity is regulated in situ by CvkR, an unusual MerR family regulator.
- Marcus Ziemann
- , Viktoria Reimann
- & Wolfgang R. Hess
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Article
| Open AccessEnhanced regulation of prokaryotic gene expression by a eukaryotic transcriptional activator
Expanded toolkits for prokaryotic synthetic biology can enhance the dynamic range of gene expression. Here the authors move the eukaryotic transcription factor QF into E. coli and integrate it into genetic devices.
- I. Cody MacDonald
- , Travis R. Seamons
- & Tara L. Deans