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| Open AccessDissociable roles of human frontal eye fields and early visual cortex in presaccadic attention
It has been unclear whether human FEF and early visual cortex play a role in the perceptual modulations preceding saccades. Here, the authors show that V1/2 TMS reduces sensitivity at the contralateral target just before saccade onset, and rFEF+TMS enhances sensitivity where presaccadic perception is poor.
- Nina M. Hanning
- , Antonio Fernández
- & Marisa Carrasco
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Article
| Open AccessMultidimensional cerebellar computations for flexible kinematic control of movements
Moving precisely in natural environments requires adapting to multiple demands arising dynamically. Here, the authors show that the cerebellum’s capacity for multidimensional computations allows it to flexibly control multiple movement parameters guaranteeing movement precision.
- Akshay Markanday
- , Sungho Hong
- & Peter Thier
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Article
| Open AccessTopographic organization of eye-position dependent gain fields in human visual cortex
It is not fully understood how sensory ambiguity introduced by eye movements is resolved by the visual system. Here, the authors use an encoding model to capture gain modulation of visual responses in 7 T fMRI data.
- Jasper H. Fabius
- , Katarina Moravkova
- & Alessio Fracasso
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| Open AccessV1-bypassing suppression leads to direction-specific microsaccade modulation in visual coding and perception
How microsaccades modulate visual coding and perception remains incompletely understood. Here, the authors identify an emerging suppression specific to microsaccade directions that alters responses in macaque V2 and impacts perceptual decisions.
- Yujie Wu
- , Tian Wang
- & Dajun Xing
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Article
| Open AccessConserved subcortical processing in visuo-vestibular gaze control
Here, the authors show that gaze stabilization relies on a visuo-vestibular network conserved from lamprey to primates. This primordial blueprint highlights how visual and vestibular streams are organized to control fundamental aspects of eye movements.
- Tobias Wibble
- , Tony Pansell
- & Juan Pérez-Fernández
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Article
| Open AccessA conflict between spatial selection and evidence accumulation in area LIP
In primate area LIP, target selection and the accumulation of sensory evidence are considered a single process. Here, the authors use urgent choice tasks to show that spatial selection in LIP is distinct from, and may even conflict with, evidence accumulation.
- Joshua A. Seideman
- , Terrence R. Stanford
- & Emilio Salinas
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Article
| Open AccessNeural signals regulating motor synchronization in the primate deep cerebellar nuclei
It remains unclear how the brain represents information regarding synchronized movements. Here, the authors investigated the response properties of cerebellar cells in macaques performing a synchronized saccade task and found three groups of cerebellar neurons with distinct peri-saccade response profiles.
- Ken-ichi Okada
- , Ryuji Takeya
- & Masaki Tanaka
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Article
| Open AccessFixational drift is driven by diffusive dynamics in central neural circuitry
Between saccades, our eyes undergo random movements called fixational drift, but what drives this motion has remained elusive. In this paper, the authors demonstrate that a central neural circuit within the oculomotor system drives fixational drift.
- Nadav Ben-Shushan
- , Nimrod Shaham
- & Yoram Burak
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Article
| Open AccessRamp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades
The neural mechanisms by which the brain initiates self-generated actions are unclear. The authors show, using population imaging and single-cell ablation, that ramp-to-threshold firing dynamics over multiple seconds is critical for the initiation of self-generated eye movements.
- Alexandro D. Ramirez
- & Emre R. F. Aksay
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Article
| Open AccessTransforming absolute value to categorical choice in primate superior colliculus during value-based decision making
Value-based decision making involves choosing from multiple options with different values. The authors identify a neural mechanism that directly transforms absolute values to categorical choices within the superior colliculus and which supports value-based decision making critical for real-world economic behaviours.
- Beizhen Zhang
- , Janis Ying Ying Kan
- & Michael Christopher Dorris
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Article
| Open AccessOculomotor freezing reflects tactile temporal expectation and aids tactile perception
The oculomotor system keeps the eyes steady in expectation of visual events, inhibiting small fixational eye movements. Here, the authors reveal that this oculomotor freezing reflects tactile temporal expectations and aids tactile perception.
- Stephanie Badde
- , Caroline F. Myers
- & Marisa Carrasco
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Article
| Open AccessFinely tuned eye movements enhance visual acuity
Humans are normally not aware that their eyes are always in motion, even when attempting to maintain steady gaze on a point. Here the authors show that these small eye movements are finely controlled and contribute more than two lines in a standard eye-chart test of visual acuity.
- Janis Intoy
- & Michele Rucci
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Article
| Open AccessDigit-tracking as a new tactile interface for visual perception analysis
Eye‐tracking is a valuable tool in cognitive science for measuring how attention is directed during visual scene exploration. Here, the authors introduce a new, touchscreen-based method that accomplishes the same goal via tracking finger movements.
- Guillaume Lio
- , Roberta Fadda
- & Angela Sirigu
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Article
| Open AccessMemory-guided microsaccades
Microsaccades are small-amplitude, fixational eye movements that are largely thought to be involuntary. Here, the authors demonstrate that monkeys (and humans) can be easily trained to respond to a remembered target location with a volitional microsaccade, and that a population of superior colliculus neurons is selectively associated with them.
- Konstantin F. Willeke
- , Xiaoguang Tian
- & Ziad M. Hafed
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Article
| Open AccessA neuronal correlate of insect stereopsis
The praying mantis, a predatory insect, estimates depth via binocular vision. In this way, the animal decides whether prey is within reach. Here, the authors explore the neural correlates of binocular distance estimation and report that individual neurons are tuned to specific locations in 3D space.
- Ronny Rosner
- , Joss von Hadeln
- & Jenny C. A. Read
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Article
| Open AccessFunctional ultrasound imaging of the brain reveals propagation of task-related brain activity in behaving primates
Neuroimaging modalities such as MRI and EEG are able to record brain activity, but spatiotemporal resolution and sensitivity are limited. Here, the authors show how a recently developed method, functional ultrasound imaging (fUS), can measure brain activation during cognitive tasks in primates.
- Alexandre Dizeux
- , Marc Gesnik
- & Mickael Tanter
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Article
| Open AccessDissecting the circuit for blindsight to reveal the critical role of pulvinar and superior colliculus
Blindsight refers to visual behaviours that are spared following lesions to the primary visual cortex and is thought to involve pulvinar circuits. Here, the authors report that selective inactivation of the ventral pulvinar or the superior colliculus leads to impairment in visually guided saccades in blindsight.
- Masaharu Kinoshita
- , Rikako Kato
- & Tadashi Isa
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Article
| Open AccessEye activity tracks task-relevant structures during speech and auditory sequence perception
Our eyes constantly follow objects we see, but do they also move in synchrony with auditory inputs? Here, the authors show that eyelid movements track the temporal structure of speech and other sound sequences, which could reflect a role of motor systems in temporal attention and sequence processing.
- Peiqing Jin
- , Jiajie Zou
- & Nai Ding
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Article
| Open AccessSaccade metrics reflect decision-making dynamics during urgent choices
Saccades have been extensively used to report choices in perceptual decision making studies yet little is known about the influence of covert decision-related processes on saccade metrics. Here, the authors demonstrate that saccade kinematics is a reliable tell about the degree of decision certainty.
- Joshua A. Seideman
- , Terrence R. Stanford
- & Emilio Salinas
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Article
| Open AccessSpatial frequency sensitivity in macaque midbrain
In primates, the superior colliculus (SC) contributes to rapid visual exploration with saccades. Here the authors show that the superior colliculus preferentially represents low spatial frequencies, which are the most prevalent in natural scenes.
- Chih-Yang Chen
- , Lukas Sonnenberg
- & Ziad M. Hafed
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| Open AccessSaccade-synchronized rapid attention shifts in macaque visual cortical area MT
Saccades result in remapping the neural representation of a target object as well as its attentional modulation. Here the authors show that the trans-saccadic attentional shift is precisely synchronized with the saccade resulting in optimal maintenance of the locus of spatial attention.
- Tao Yao
- , Stefan Treue
- & B. Suresh Krishna
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Article
| Open AccessEvidence for a task-dependent switch in subthalamo-nigral basal ganglia signaling
Basal ganglia can both facilitate or inhibit movement through excitatory and inhibitory pathways; however whether these opposing signals are dynamically regulated during behavior is not known. Here the authors use multinucleus LFP recordings and electrical microstimulation in monkeys performing saccade based tasks to show task specific changes in the tonic weighting of these pathways.
- Jay J. Jantz
- , Masayuki Watanabe
- & Douglas P. Munoz
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Article
| Open AccessHeading representations in primates are compressed by saccades
Macaque higher visual areas MST and VIP encode heading direction based on self-motion stimuli. Here the authors show that, while making saccades, the heading direction decoded from the neural responses is compressed toward straight-ahead, and independently demonstrate a perceptual illusion in humans based on this perisaccadic decoding error.
- Frank Bremmer
- , Jan Churan
- & Markus Lappe
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Article
| Open AccessSensorimotor computation underlying phototaxis in zebrafish
Active locomotion requires closed-loop sensorimotor co ordination between perception and action. Here the authors show using behavioural, imaging and modelling approaches that gaze orientation during phototaxis behaviour in larval zebrafish is related to oscillatory dynamics of a neuronal population in the hindbrain.
- Sébastien Wolf
- , Alexis M. Dubreuil
- & Georges Debrégeas
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Article
| Open AccessSuperior colliculus neurons encode a visual saliency map during free viewing of natural dynamic video
Saliency maps have been proposed to guide visual attention, yet the underlying neural correlates remain undetermined. Here, the authors record from monkeys as they watch videos of natural scenes, and find superior colliculus superficial visual-layer neurons exhibit activity patterns consistent with a visual saliency map.
- Brian J. White
- , David J. Berg
- & Douglas P. Munoz
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Article
| Open AccessSpatially precise visual gain control mediated by a cholinergic circuit in the midbrain attention network
Attention and gaze impact the spatial responsiveness of neurons in the optic tectum. Here the authors elucidate the mechanism by which cholinergic inputs affect receptive field properties of tectal neurons in a spatially precise manner in barn owls.
- Ali Asadollahi
- & Eric I. Knudsen
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Article
| Open AccessPlasticity within non-cerebellar pathways rapidly shapes motor performance in vivo
The extent to which non-cerebellar pathways can refine motor performance is debated. Here, the authors demonstrate behaviourally relevant patterns of activation evoke rapid plasticity within direct and indirect vestibulo-ocular reflex pathways in vivo, leading to changes in evoked eye movements.
- Diana E. Mitchell
- , Charles C. Della Santina
- & Kathleen E. Cullen
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Article
| Open AccessMicroglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
Microglia play key roles during early neurodevelopment. Here the authors show that microglia are important mediators of ocular dominance plasticity (ODP). Microglia respond to monocular deprivation during the visual critical period, and disrupting microglial P2Y12 purinergic receptor abrogates ODP.
- G. O. Sipe
- , R. L. Lowery,
- & A. K. Majewska
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Article
| Open AccessCalcium imaging of sleep–wake related neuronal activity in the dorsal pons
Dreaming occurs in REM sleep, yet the neural mechanisms involved in generating it are not understood. Here Cox and colleagues show that glutamatergic neurons in the dorsal pons are activated most during transition to REM sleep while GABAergic neurons are more active during waking state.
- Julia Cox
- , Lucas Pinto
- & Yang Dan
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Article
| Open AccessTwo distinct types of remapping in primate cortical area V4
Visual receptive fields are known to change positions around the time of a saccade, but the nature of this remapping is unclear. Here Neupane and colleagues show that neurons in area V4 of the visual cortex exhibit two types of remapping, one consistent with a role in maintaining perceptual stability, and a second that seems to reflect shifts of attention.
- Sujaya Neupane
- , Daniel Guitton
- & Christopher C. Pack
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Article
| Open AccessSerotonin neurons in the dorsal raphe nucleus encode reward signals
How neurons in the dorsal raphe nucleus (DRN) respond to reward related behaviours is not known. Here, Li and colleagues report that DRN serotoninergic neurons are phasically activated by rewards such as sex, food and sucrose, and tonically activated during reward anticipation, while GABAergic neurons respond to punishment.
- Yi Li
- , Weixin Zhong
- & Minmin Luo
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Article
| Open AccessTesting necessary regional frontal contributions to value assessment and fixation-based updating
In value-based decisions, the longer one fixates on an option, the more likely one is to choose it. Here, the authors compare the performance of people with focal frontal lobe damage in a simple choice task and show that damage to the dorsomedial PFC leads to exaggerated fixation-related value updating.
- Avinash R. Vaidya
- & Lesley K. Fellows
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Article
| Open AccessBasal forebrain control of wakefulness and cortical rhythms
The mammalian basal forebrain controls cortical rhythm and wake-sleep. Anaclet et al.use genetically-targeted chemogenetic systems to activate or inhibit cholinergic, glutamatergic or GABAergic neurons in this region, and reveal their contributions to behavioral and electrocortical arousal in behaving mice.
- Christelle Anaclet
- , Nigel P. Pedersen
- & Patrick M. Fuller
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| Open AccessNeuronal and behavioural modulations by pathway-selective optogenetic stimulation of the primate oculomotor system
Pathway-selective optogenetics enables the precise control of neural activity in targeted pathways connecting specific brain regions. Here the authors provide the first demonstration that pathway-selective optogenetics can modulate neural activity and behaviour in non-human primates.
- Ken-ichi Inoue
- , Masahiko Takada
- & Masayuki Matsumoto
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Article
| Open AccessSaccadic modulation of stimulus processing in primary visual cortex
Primates acquire visual information through rapid saccadic eye movements, although little is known about their effects on neural processing of visual inputs. Here the authors demonstrate that saccades produce modulations of visual cortical processing that likely originate in the thalamus.
- James M. McFarland
- , Adrian G. Bondy
- & Daniel A. Butts
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Article
| Open AccessV1 neurons respond differently to object motion versus motion from eye movements
A key question in neuroscience is understanding how the brain distinguishes self-generated motion from motion in the external world. Here the authors demonstrate that the response of primary visual cortical neurons to a moving stimulus depends on whether the motion was self- or externally generated.
- Xoana G. Troncoso
- , Michael B. McCamy
- & Susana Martinez-Conde
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Multisensory training reverses midbrain lesion-induced changes and ameliorates haemianopia
Failure to attend to visual cues is a common consequence of visual cortical injury. Here, the authors demonstrate that auditory–visual cross-modal behavioural training leads to neural plasticity and reinstatement of visuomotor competency in animals rendered unilaterally blind by visual cortical removal.
- Huai Jiang
- , Barry E. Stein
- & John G. McHaffie
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Article
| Open AccessProcessing of visually evoked innate fear by a non-canonical thalamic pathway
The ability of animals to respond to life-threatening stimuli is critical for survival, yet the neural circuits mediating innate defensive behaviors are not well understood. Here, the authors reveal a novel collicular–thalamic–amygdala circuit critical for innate defensive responses to visual threats.
- Pengfei Wei
- , Nan Liu
- & Liping Wang
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Article
| Open AccessPreference for concentric orientations in the mouse superior colliculus
The mammalian superior colliculus (SC) processes visual stimuli but little is known about the spatial organization of the response preferences for specific visual features. Here the authors show that the mouse SC contains a map for orientation preference such that preferred grating orientation is aligned to concentric circles around the centre of the visual field.
- Mehran Ahmadlou
- & J Alexander Heimel
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Predicting oculomotor behaviour from correlated populations of posterior parietal neurons
Cortical brain signals are often studied by predicting sensory inputs and behaviours from ensembles of neurons, but the uncertainty of these predictions is poorly understood. Graf and Andersen show that the level of uncertainty is reduced when populations of cortical neurons exhibit correlated variability.
- Arnulf B. A. Graf
- & Richard A. Andersen
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Development of oculomotor circuitry independent of hox3 genes
Hox genes have been implicated in the development and functioning of neural circuits in vertebrates. Here, the authors show that although hox3genes are not required for overall neural circuit development, they do appear to be necessary to prevent the formation of specific aberrant neuronal connections.
- Leung-Hang Ma
- , Charlotte L. Grove
- & Robert Baker
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Extracellular matrix inhibits structural and functional plasticity of dendritic spines in the adult visual cortex
Neuronal connectivity in the mature brain is stabilized by the extracellular matrix. This study shows that degradation of chondroitin sulfate proteoglycans in the matrix increases connectivity in the adult cortex by causing a large increase in motility and functional plasticity of dendritic spines.
- L. de Vivo
- , S. Landi
- & G.M. Ratto
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Developmental correspondence between action prediction and motor ability in early infancy
It is believed that infants map observed actions onto their own representation of the action, a hypothesis known as direct matching. By observing the gaze of infants and their grasping response, experimental evidence is provided to support the direct matching theory.
- Yasuhiro Kanakogi
- & Shoji Itakura