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A real-world study of 100 diverse cases facilitated by a single centre for individualized bacteriophage therapy demonstrates feasibility and provides new hope for refractory and resistant bacterial infections.
Analysis of 100 consecutive personalized bacteriophage therapy cases supports the use of personalized and sometimes pre-adapted, bacteriophage preparations, often in combination with antibiotics.
With metabolic syndrome links to gut microbiome imbalance, authors show that transplantation of modified lean fecal donor viromes alleviate metabolic syndrome symptoms in obese mice.
Current methods quantifying phage lytic efficacy have limits. Centroid Index quantifies efficacy via the center of area, offering more accuracy. For calculation of this index, a software called Centroid Index Calculator is presented.
A real-world study of 100 diverse cases facilitated by a single centre for individualized bacteriophage therapy demonstrates feasibility and provides new hope for refractory and resistant bacterial infections.
Reporting in Nature Communications, Huo and colleagues provide three-dimensional structures of a bacterial immune defense system called Gabija. This work builds on recently published structural and functional studies and contributes strong evidence that protein assembly formation is essential for antiviral function.
We deeply characterized the early-life gut virome, which consists mainly of bacteriophages (phages) and the diversity of which greatly exceeds bacterial diversity. The virome was associated with later asthma development, independently of the bacterial hosts of the phages; we further uncovered intriguing interactions with immune genetics.
Two recent studies provide mechanistic understanding of how bacteria employ the Gabija system for defence against phages, as well as how phages use anti-defence proteins to overcome bacterial immunity.
