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Whether and how sharp-wave ripples (SWRs) accompany mental states that are less closely linked to events in the immediate environment are not fully understood. Here authors recorded SWRs from hippocampus of 10 epilepsy patients for up to 15 days with experience sampling. SWR rates showed circadian fluctuation and were associated with self-generated thoughts such as mind wandering.
Archaeological and genetic evidence suggest differing scenarios for human migration out of Africa. Here, the authors present archaeological evidence of intense occupation in Wallacea from 44 thousand years ago, suggesting that this occupation obscured genetic evidence of earlier dispersals.
Cardiovascular events (CVEs) are the leading cause of death among hip fracture patients. Here, the authors show the findings on subphenotyping the heterogeneous spectrum of hip fracture patients in both Hong Kong and the United Kingdom older adult populations and temporal associations with CVEs across all subphenotypes.
Here, the authors present MTAC, a method to map chromosomal interactions in budding yeast. By applying MTAC to various viewpoints, they find that most of the long-distance chromosomal interactions detected by MTAC reflect tethering by the nuclear pore complexes.
Allylic substitution reaction of alkenes has been well-developed, but it has limitations, partly due to the intrinsic predilection for an inner-sphere mechanism. Herein, the authors present an outer-sphere mechanism in Rh-catalyzed allylic substitution reaction of simple alkenes using gem-difluorinated cyclopropanes as allyl surrogates.
Charge loss at grain boundaries of kesterite polycrystalline absorbers limits the performance of thin film solar cells. Here, authors report the use of Pd(II)/Pd(IV) redox shuttle to assist the capture and exchange of Se atoms and eliminate vacancy defects, realizing certified efficiency of 14.3%.
The array of tools to image peroxisome regulation is still limited. Here, the authors develop improved fatty acid-based probes with high peroxisome specificity and bright fluorescence in the red/far-red spectrum, which makes them ideal to study peroxisomes in live cells and whole organisms.
Frustrated magnetic systems typically have multiple ground state configurations. While such multistability is common in amorphous materials, periodic mechanical systems have long range elastic interactions that tend to lead to a long-range ordered ground state. Herein, Sirote-Katz, Shohat et al. introduce periodic mechanical systems that have many disordered metastable states.
Copper isotopes in rifted alkaline rocks indicate that since the Neoproterozoic, cratonic mantle roots have been oxidized from metal-saturated environments with volatile CH4 and H2O to environments of stabilized CO2 and H2O and destabilized metals.
The role of non-coding mutations in cancer progression and immune evasion needs to be further explored. Here, the authors investigate the potential of common somatic and germline 3′ untranslated region variants in predicting response to immunotherapy in gastric patients.
Photoreceptor outer segment abnormalities cause retinitis pigmentosa, a form of blindness. Here, authors show that the disease-associated gene RPGR regulates actin-mediated outer segment turnover through its interaction with the actin severer, cofilin.
In this study, a deep learning-based model of left atrial size in UK Biobank enabled genome-wide association studies in 35,049 healthy participants. Several lines of evidence, including the PITX2 locus, linked left atrial dysfunction to atrial fibrillation risk.
How the hippocampus selects relevant events that are worth remembering is debated. Here, authors show midbrain dopamine neurons projecting to the hippocampus provide a teaching signal triggering NeoHebbian LTP and contextual learning.
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a major class of natural products with potent biological activities but a vast majority of RiPP gene clusters remain unexplored in microbial genomes. Here, the authors report a unified biocatalysis (UniBioCat) system based on cell-free gene expression for rapid biosynthesis and engineering of RiPPs.
There are no approved interventions for Hendra or Nipah viruses. Here, the authors isolate a G glycoprotein-specific antibody with cross-neutralizing and in vivo protective activities, and structurally resolve its binding pattern to the G protein.
Chromatin within interphase nuclei forms compacted nanoscale DNA domains of uniform size. By integrating theory and imaging, here the authors show how the interplay between transcription and epigenetic mechanisms determine this size, independent of cell type.
Two-dimensional graphene-based membranes have gained much interest, but they suffer from poor rejection for monovalent salts. Here, the authors develop an electrostatic-induced ion partitioning strategy to suppress anion-cation transmembrane co-transport, improving the desalination performance.
Whether decisions are made in a graded or all-or-none fashion remains unclear. Here, the authors provide evidence to suggest that decisions conclude in a graded, rather than a binary, manner, thus providing an analog framework for flexible choice behavior.
The parental experience exerts a profound impact on offspring phenotypes. Zhu et al. find that in locusts the population density of parents regulates the hatching synchrony of progeny eggs via the FOXN1-PTBP1/XPO5 pathway, facilitating the nuclear export of precursor miRNA in the oocytes.
The advancement of sodium halide solid-state electrolytes can propel high-energy-density all-solid-state sodium-ion batteries. Here, the authors present a LaCl3-based electrolyte facilitating rapid Na+ ion conduction along the c-axis diffusion channel, ensuring high capacity even at elevated current densities.