Organogenesis articles within Nature

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  • Article
    | Open Access

    In fruit flies, three-dimensional organ arrangement is stereotypical, sexually dimorphic and actively maintained by muscle-vessel mechanochemical crosstalk.

    • Laura Blackie
    • , Pedro Gaspar
    •  & Irene Miguel-Aliaga

  • Article
    | Open Access

    Combining single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization reveals in detail the cellular interactions and specialization of cardiac cell types that form and remodel the human heart.

    • Elie N. Farah
    • , Robert K. Hu
    •  & Neil C. Chi

  • Article
    | Open Access

    Using single-cell and spatial transcriptomics, human embryonic limb development across space and time and the diversification and cross-species conservation of cells are demonstrated.

    • Bao Zhang
    • , Peng He
    •  & Sarah A. Teichmann

  • Article |

    Complementary single-cell and single-nucleus transcriptomic analyses of Zea mays, Sorghum bicolor and Setaria viridis root cells provide insights into the evolution of cell types and gene modules that control key traits in these important crop species.

    • Bruno Guillotin
    • , Ramin Rahni
    •  & Kenneth D. Birnbaum

  • Article
    | Open Access

    In-depth transcriptomic analyses of 56,636 single cells from monkey embryos revealed transcriptional features of major perigastrulation cell types, and comparative analyses with mouse embryos and human embryoids uncovered conserved and divergent features of perigastrulation development across species.

    • Jinglei Zhai
    • , Jing Guo
    •  & Hongmei Wang

  • Article
    | Open Access

    Synthetic mouse embryos assembled from embryonic stem cells, trophoblast stem cells and induced extraembryonic endoderm stem cells closely recapitulate the development of wild-type and mutant natural mouse embryos up to embryonic day 8.5.

    • Gianluca Amadei
    • , Charlotte E. Handford
    •  & Magdalena Zernicka-Goetz

  • Article |

    Live imaging and single-cell transcriptomics of mouse hair follicles reveal their development from 2D concentric zones in the placode to 3D longitudinal compartments, one of which is a stem cell compartment.

    • Ritsuko Morita
    • , Noriko Sanzen
    •  & Hironobu Fujiwara

  • Article |

    Lymphatic endothelium secretes factors needed for heart growth and repair such as RELN, which helps with heart regeneration and cardioprotection after myocardial infarction.

    • Xiaolei Liu
    • , Ester De la Cruz
    •  & Guillermo Oliver

  • Article |

    Single-cell analysis of blood vessels in the alveolus, the site of chronic disease and virus-induced lung injury, reveals two intermingled endothelial cell types with specialized gas exchange and stem cell functions.

    • Astrid Gillich
    • , Fan Zhang
    •  & Ross J. Metzger

  • Article |

    Miniature gut tubes grown in vitro from mouse intestinal stem cells are perfusable, can be colonized with microorganisms and exhibit a similar arrangement and diversity of specialized cell types to intestines in vivo.

    • Mikhail Nikolaev
    • , Olga Mitrofanova
    •  & Matthias P. Lutolf

  • Article |

    The transient reactivation of ETV2 in adult human endothelial cells reprograms these cells to become adaptable vasculogenic endothelia that in three-dimensional matrices self-assemble into vascular networks that can transport blood and physiologically arborize organoids and decellularized tissues.

    • Brisa Palikuqi
    • , Duc-Huy T. Nguyen
    •  & Shahin Rafii

  • Article |

    Skin organoids generated in vitro from human pluripotent stem cells form complex, multilayered skin tissue with hair follicles, sebaceous glands and neural circuitry, and integrate with endogenous skin when grafted onto immunocompromised mice.

    • Jiyoon Lee
    • , Cyrus C. Rabbani
    •  & Karl R. Koehler

  • Article |

    A system involving in vitro induction of presomitic mesoderm recapitulates oscillatory expression of core segmentation clock genes and travelling-wave-like gene expression, suggesting that this system can be used to study the human segmentation clock and provide insights into diseases associated with human axial skeletogenesis.

    • Mitsuhiro Matsuda
    • , Yoshihiro Yamanaka
    •  & Cantas Alev

  • Article |

    RITF1, a newly identified plant transcription factor, links signalling through the peptide hormone RGF1 to the balance of reactive oxygen species and thereby enhances the stability of another transcription factor, PLETHORA2, a master regulator of root stem cells.

    • Masashi Yamada
    • , Xinwei Han
    •  & Philip N. Benfey

  • Article |

    A transcriptome dataset from seven organs and seven mammalian species throughout development is used to analyse the expression of long noncoding RNAs in tissues within and between species, and at different stages of organ development.

    • Ioannis Sarropoulos
    • , Ray Marin
    •  & Henrik Kaessmann

  • Article |

    The transcriptomes of seven major organs across developmental stages from several mammalian species are used for comparative analyses of gene expression and evolution across organ development.

    • Margarida Cardoso-Moreira
    • , Jean Halbert
    •  & Henrik Kaessmann

  • Letter |

    The in vitro generation, from pluripotent stem cells, of three-dimensional human gastric organoids (hGOs) that contain a physiological gastric epithelium comprising both progenitor and differentiated cell types, and have expected functional characteristics is described, as is modelling the pathophysiological response of the human stomach to Helicobacter pylori using these hGOs.

    • Kyle W. McCracken
    • , Emily M. Catá
    •  & James M. Wells

  • Letter |

    A new approach has been developed in order to achieve the stepwise differentiation of inner ear sensory epithelia from mouse embryonic stem cells in a three-dimensional culture: this process, which mimics normal development and produces cells that have functional characteristics of mechanosensitive hair cells, is hoped to provide further insights into inner ear development and disorder.

    • Karl R. Koehler
    • , Andrew M. Mikosz
    •  & Eri Hashino

  • Letter |

    This phylogenomic study shows that core muscle proteins were already present in unicellular organisms before the origin of multicellular animals, and supports a convergent evolutionary model for striated muscles in which new proteins are added to ancient contractile apparatus during independent evolution of bilaterians and some non-bilaterians, resulting in very similar ultrastructures.

    • Patrick R. H. Steinmetz
    • , Johanna E. M. Kraus
    •  & Ulrich Technau

  • News & Views |

    Developing organs adapt dynamically to meet the changing needs of a growing organism. A study in zebrafish reveals surprising patterns of muscle growth that reshape the heart as it matures. See Article p.479

    • Deborah Yelon

  • News & Views |

    Skin-cancer stem cells secrete a factor that organizes a blood-supply system to fuel tumour growth. But the same factor has another sinister function — it stimulates the stem cells to propagate uncontrollably. See Letter p.399

    • Salvador Aznar Benitah

  • Letter |

    These authors describe a molecular pathway by which endothelial cells sustain liver regeneration after surgical resection. Activation of vascular endothelial growth factor-A receptor-2 in a defined subpopulation of liver endothelial cells leads to the upregulation of the endothelial-specific transcription factor Id1, which in turn induces Wnt2 and hepatocyte growth factor, which are secreted from the endothelial cells and trigger hepatocyte proliferation.

    • Bi-Sen Ding
    • , Daniel J. Nolan
    •  & Shahin Rafii

  • News |

    The drug stunts limb development in zebrafish and chicks by binding to a protein called cereblon.

    • Janet Fang

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