Medical research articles within Nature

Featured

  • Editorial |

    The time is ripe for Europe's scientists to lobby for community-wide infrastructure funding.

  • News & Views |

    DNA is particularly well preserved in hair — enabling the genome of a human to be sequenced, and his ancestry and appearance to be determined, from 4,000-year-old remains.

    • David M. Lambert
    •  & Leon Huynen

  • Article |

    To survive and evade host responses, malaria parasites export several hundred proteins into the host cell on infection. A feature of these proteins is a conserved, pentameric motif that is cleaved by an unknown protease before export. This is one of two independent studies revealing the identity of the protease as plasmepsin V, an aspartic acid protease located in the endoplasmic reticulum. This enzyme is essential for parasite viability and is an attractive candidate for drug development.

    • Ilaria Russo
    • , Shalon Babbitt
    •  & Daniel E. Goldberg

  • Career Brief |

    Fellowship aims to boost collaborative research at European academic institutions and industrial labs.

  • Column |

    Innovation policies are more likely to be successful if they leverage existing capabilities, argues Daniel Sarewitz.

    • Daniel Sarewitz

  • Article |

    The integrase protein of retroviruses such as HIV-1 catalyses insertion of the viral genome into that of the host. Here, the long-awaited structure of the full-length integrase complex is predicted, revealing not only details of the biochemistry of the integration reaction, but also the means by which current inhibitors affect this process.

    • Stephen Hare
    • , Saumya Shree Gupta
    •  & Peter Cherepanov

  • Editorial |

    The reporting of candidate biomarkers for disease must be rigorous to drive translational research.

  • Editorial |

    By opening up its database of potential malaria drugs, GlaxoSmithKline has blazed a path that other pharmaceutical companies should follow.

  • News Feature |

    Alan Ashworth took a cancer drug from Petri dish to patients in near record speed. Daniel Cressey meets a biologist who is evangelical about translational research.

    • Daniel Cressey

  • Column |

    Quantitative research assessment is a bad idea whose time has come, argues Colin Macilwain.

    • Colin Macilwain

  • Editorial |

    Science in Canada cannot realize its full potential without clear direction from government.

  • Opinion |

    A lack of coordination in Arctic research funding leaves scientists without the support they need for fieldwork. John England outlines how Canada can set things right, and show leadership in the north.

    • John England

  • Editorial |

    There are many ways in which the understanding and treatment of conditions such as schizophrenia are ripe for a revolution.

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