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Gibbons et al. show that T cells in newborns, previously thought to have a limited ability to fight infection, can produce interleukin-8, an effector of innate immunity.
The G protein–coupled receptor F2rl1 translocates from the plasma membrane to the nucleus of retinal ganglion neurons to control Vegfa expression and retinal angiogenesis.
External blood-cleansing device for rapidly removing microorganisms and endotoxins from blood without first needing to identify the source of the infection.
In multiple sclerosis and experimental autoimmune encephalomyelitis, astrocytes produce lactosylceramide, a glycolipid that promotes astrocyte and microglial activation and immune cell infiltration into the CNS.
An in vivo RNAi dropout screen identifies Mapk14 as a new mediator of sorafenib resistance in hepatocellular carcinoma, and Mapk14 inhibition both improves sorafenib therapy and restores sensitivity to sorafenib-resistant tumors.
Genetic deletion of the lysosomal Ca2+ channel MCOLN1 in mice results in muscular dystrophy, implicating this source of calcium in muscle membrane repair.
Rampias et al. report that inactivating mutations in Notch pathway components are frequent in human bladder cancer and drive bladder tumorigenesis in mice.
Activation of the insulin-like growth factor 1 receptor may underlie clinical resistance to inhibition of the anaplastic lymphoma receptor kinase in lung cancer.
Deficiency in Gnas, encoding the Gs protein α subunit, is sufficient to induce medulloblastoma in mice due to derepression of the Sonic hedgehog pathway.
Cytotoxic T cells are necessary and sufficient for the development of alopecia areata in mice, while JAK inhibition promotes regrowth of hair in patients and mice with established disease.
Proteomic-imaging analysis of caveolae shows active transvascular pumping of antibodies across the endothelial cell barrier and into solid tumors against a concentration gradient.