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Machine learning applied to electronic health records in two US cohorts from the RECOVER initiative identified four Long-COVID subphenotypes that differ in the involvement of organ systems, previous SARS-CoV-2 infection severity and underlying conditions.
Longitudinal study of plasma biomarkers, in two independent cohorts, highlighted only p-tau217 as a surrogate marker of disease progression in early Alzheimer’s disease, supporting the development of new disease-modifying treatments.
An mRNA-based vaccine encoding antigens from all known influenza virus A and B subtypes worked well in animal models — which offers hope for broad protection in humans.
To prevent irreversible organ damage, an infant with early-onset Pompe’s disease was treated in utero; early data suggest improved outcomes and safety of this approach.
Cerebrospinal fluid measures of isoform-specific tau species from the microtubule-binding region serve as the first fluid biomarkers of primary tauopathy.
Carbon-containing particulates accumulate with age in a subset of macrophages in human lung-associated lymph nodes, decrease macrophage phagocytic capacity and turnover and disrupt lymphoid tissue structure, potentially compromising adaptive immune responses.
According to 2020 estimates from 185 countries, Asia and Africa have the most maternal orphans due to cancer, with breast and cervical cancers responsible for almost half of maternal cancers.
Nature Medicine explores the latest translational and clinical research news, with news that sotatercept met its primary endpoint in the STELLAR trial.
To enable large-scale screening for left ventricular dysfunction — a serious and under-detected cardiac disease — we applied artificial intelligence to electrocardiograms recorded by patients using their own Apple watches in a prospective, digital, remote study. We found that patients engaged with the system and that the watch electrocardiograms effectively screened for the disease.
In this proof-of-concept prospective study, single-lead electrocardiograms obtained by smartwatches were able to identify individuals with left ventricular dysfunction, potentially serving as an early warning system for heart failure.
In a first in-human study, researchers used an array of technologies to generate highly personalized cell therapy products for patients with solid tumors.
Changing gloves and instruments before wound closure significantly reduces the infection rate, offering a low-cost and impactful way to mitigate this global problem.
Impaired glucose tolerance (IGT) is a common condition that affects glucose control after sugar consumption. Isolated IGT is undetected by screening and diagnostic strategies, leaving affected individuals at high risk of developing diabetes. Here, a machine-learning framework identifies a three-protein signature for detecting isolated IGT from a single blood sample.
Circulating tumor DNA (ctDNA) informs predictive biomarkers in non–small-cell lung cancer, but the presence of ctDNA itself could also be a prognostic indicator.
99% of clinical trials for Alzheimer’s disease fail to show positive results, but researchers remain optimistic that new disease-modifying treatments are on the horizon
Abnormal amyloid and tau PET in cognitively unimpaired individuals is strongly associated with short-term cognitive decline and subsequent development of dementia.