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False-positive human immunodeficiency virus nuclear acid amplification technique testing following therapy with transgenic T cell receptor cellular therapy for synovial sarcoma

Bone Marrow Transplantation (2024)Cite this article

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Cellular engineering with gene transduction systems has produced potential treatment options for advanced malignancies, immune deficiencies and hemoglobinopathies [1]. Multiple therapeutic approaches are under investigation, including transduction of autologous T cells with genetically modified T cell receptors (TCRs) to tumor-associated antigens. This approach is considered especially promising in solid tumors, which respond poorly to chimeric antigen receptor (CAR) T cells [2].

Multiple gene transduction systems are used, including viral- and non-viral-based methods [3]. Viral-based methods are the most common due to their efficient transduction, but have potential drawbacks [1]. One significant issue is false positive human immunodeficiency virus (HIV) tests, which have been reported post-CAR T cell infusion [4,5,6]. They have not been reported with other genetically modified TCR therapies, such as affinity-enhanced TCR T cells.

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Authors and Affiliations

  1. Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA

    Michael Slade, Brian A. Van Tine & Armin Ghobadi

  2. Department of Sarcoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Dejka Araujo & Min Du

  3. Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, USA

    Bijal Parikh & Neil Anderson

  4. Division of Pediatric Hematology/Oncology, St. Louis Children’s Hospital, Saint Louis, MO, USA

    Brian A. Van Tine

  5. Siteman Cancer Center, Saint Louis, MO, USA

    Brian A. Van Tine

Authors
  1. Michael Slade
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  2. Dejka Araujo
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  3. Min Du
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  4. Bijal Parikh
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  5. Neil Anderson
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  6. Brian A. Van Tine
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  7. Armin Ghobadi
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Contributions

MS designed the study, collected data and analyzed data and drafted the manuscript. DA provided critical feedback on the study design and data interpretation. MD collected and analyzed data. BP provided critical feedback on the study design and data interpretation. NA provided critical feedback on the study design and data interpretation. BVT provided critical feedback on the study design and data interpretation. AG designed the study, analyzed data and provided criticla feedback the initial manuscript. All authors criticial reviewed the manuscript and approved the final version.

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Correspondence to Michael Slade.

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Slade, M., Araujo, D., Du, M. et al. False-positive human immunodeficiency virus nuclear acid amplification technique testing following therapy with transgenic T cell receptor cellular therapy for synovial sarcoma. Bone Marrow Transplant (2024). https://doi.org/10.1038/s41409-024-02307-1

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  • DOI: https://doi.org/10.1038/s41409-024-02307-1

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