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Unlocking the mysterious mechanisms of Myc

Nature Medicine volume 19, pages 26–27 (2013)Cite this article

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Susanne Walz & Martin Eilers

The recent exciting papers by Lin et al.1 and Nie et al.2 propose that Myc induces expression of all genes to which it is bound. The normalization inherent in current analysis methods for gene expression data eliminates a global increase in all RNAs and therefore can falsely give the impression that genes are repressed. Hence, the assumption that both transcriptional activation and repression by Myc establish a tumor-specific expression pattern is erroneous.

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Unlocking the mysterious mechanisms of Myc. Nat Med 19, 26–27 (2013). https://doi.org/10.1038/nm.3060

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