Corrigendum

Nature Reviews Neuroscience 9, 494 (June 2008) | doi:10.1038/nrn2410

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

Lorenzo A. Cingolani & Yukiko Goda

Nature Reviews Neuroscience 9, 344–356 (2008)

In Box 3 of the above article, the figure incorrectly showed CaMKK downstream of CaMKII. The figure should have shown two parallel pathways: one involving CaMKK–CaMKI signalling and another with CaMKII activating Rac1 via Kalirin-7 (see below).


Correspondingly, the 5th sentence of the text in Box 3 should read: "Among the intracellular signalling events that are relevant for actin dynamics, of particular interest is the activation of the calmodulin-dependent kinase kinase (CaMKK)–CaMKI signalling pathway."

Also, Table 1 of the above article listed incorrect references. Corrected references are shown below.


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References

  1. Nakagawa, T., Engler, J. A. & Sheng, M. The dynamic turnover and functional roles of alpha-actinin in dendritic spines. Neuropharmacology 47, 734–745 (2004).

  2. Hering, H. & Sheng, M. Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesis. J. Neurosci. 23, 11759–11769 (2003).

  3. Harigaya, Y., Shoji, M., Shirao, T. & Hirai, S. Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease. J. Neurosci. Res. 43, 87–92 (1996).

  4. Takahashi, H. et al. Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis. J. Neurosci. 23, 6586–6595 (2003).

  5. Ryu, J. et al. A critical role for myosin IIb in dendritic spine morphology and synaptic function. Neuron 49, 175–182 (2006).

  6. Libby, R. T. et al. Myosin Va is required for normal photoreceptor synaptic activity. J. Cell Sci. 117, 4509–4515 (2004).

  7. Takagishi, Y. et al. Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats. Dev. Neurobiol. 67, 909–923 (2007).

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