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Nature Medicine 9, 1413-1417 (1 November 2003) | doi:10.1038/nm949;
PML-RARA|[ndash]|targeted DNA vaccine induces protective immunity in a mouse model of leukemia
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Abstract
Despite improved molecular characterization of malignancies and development of targeted therapies, acute leukemia is not curable and few patients survive more than 10 years after diagnosis. Recently, combinations of different therapeutic strategies (based on mechanisms of apoptosis, differentiation and cytotoxicity) have significantly increased survival.
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