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Nature Medicine 9, 1404-1407 (1 November 2003) | doi:10.1038/nm945;
The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif
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Abstract
The human protein apolipoprotein B mRNA-editing enzyme–catalytic polypeptide-like-3G (APOBEC3G), also known as CEM-15, mediates a newly described form of innate resistance to retroviral infection by catalyzing the deamination of deoxycytidine to deoxyuridine in viral cDNA replication intermediates. Because DNA deamination takes place after virus entry into target cells, APOBEC3G function is dependent on its association with the viral nucleoprotein complexes that synthesize cDNA and must therefore be incorporated into virions as they assemble in infected cells.
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