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Nature Medicine 9, 1418-1422 (1 November 2003) | doi:10.1038/nm943;
G13 is an essential mediator of platelet activation in hemostasis and thrombosis
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Abstract
Platelet activation at sites of vascular injury is essential for primary hemostasis, but also underlies arterial thrombosis leading to myocardial infarction or stroke. Platelet activators such as adenosine diphosphate, thrombin or thromboxane A2 (TXA2) activate receptors that are coupled to heterotrimeric G proteins.
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