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Nature Medicine 14, 188-193 (1 February 2008) | doi:10.1038/nm1706;

Dok1 mediates high-fat diet|[ndash]|induced adipocyte hypertrophy and obesity through modulation of PPAR-|[gamma]| phosphorylation

Tetsuya Hosooka , Tetsuya Noguchi , Ko Kotani , Takehiro Nakamura , Hiroshi Sakaue , Hiroshi Inoue , Wataru Ogawa , Kazutoshi Tobimatsu , Kazuo Takazawa , Mashito Sakai , Yasushi Matsuki , Ryuji Hiramatsu , Tomoharu Yasuda , Mitchell A Lazar , Yuji Yamanashi & Masato Kasuga

Insulin receptor substrate (IRS)-1 and IRS-2 have dominant roles in the action of insulin, but other substrates of the insulin receptor kinase, such as Gab1, c-Cbl, SH2-B and APS, are also of physiological relevance. Although the protein downstream of tyrosine kinases-1 (Dok1) is known to function as a multisite adapter molecule in insulin signaling, its role in energy homeostasis has remained unclear.

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