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Nature Medicine 14, 64-68 (1 January 2008) | doi:10.1038/nm1666;
G12-G13|[ndash]|LARG|[ndash]|mediated signaling in vascular smooth muscle is required for salt-induced hypertension
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Abstract
The tone of vascular smooth muscle cells is a primary determinant of the total peripheral vascular resistance and hence the arterial blood pressure. Most forms of hypertension ultimately result from an increased vascular tone that leads to an elevated total peripheral resistance.
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