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Nature Medicine 12, 1403-1409 (1 December 2006) | doi:10.1038/nm1514;
v-ATPase V0 subunit d2|[ndash]|deficient mice exhibit impaired osteoclast fusion and increased bone formation
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Abstract
Matrix-producing osteoblasts and bone-resorbing osteoclasts maintain bone homeostasis. Osteoclasts are multinucleated, giant cells of hematopoietic origin formed by the fusion of mononuclear pre-osteoclasts derived from myeloid cells.
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