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Nature Medicine 12, 235-239 (1 February 2006) | doi:10.1038/nm1351;

Angiopoietin-2 sensitizes endothelial cells to TNF-|[alpha]| and has a crucial role in the induction of inflammation

Ulrike Fiedler , Yvonne Reiss , Marion Scharpfenecker , Verena Grunow , Stefanie Koidl , Gavin Thurston , Nicholas W Gale , Martin Witzenrath , Simone Rosseau , Norbert Suttorp , Astrid Sobke , Matthias Herrmann , Klaus T Preissner , Peter Vajkoczy & Hellmut G Augustin

The angiopoietins Ang-1 and Ang-2 have been identified as ligands of the receptor tyrosine kinase Tie-2 (refs. 1,2).

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