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Nature Medicine 11, 1104-1108 (1 October 2005) | doi:10.1038/nm1299;
Cdk5-dependent regulation of glucose-stimulated insulin secretion
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Abstract
Tight glycemic control in individuals with diabetes mellitus is essential to prevent or delay its complications. Present treatments to reduce hyperglycemia mainly target the ATP-sensitive K+ (KATP) channel of pancreatic beta cells to increase insulin secretion.
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