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Nature Medicine 11, 567-571 (1 June 2005) | doi:10.1038/nm1227;
Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action
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Abstract
Insulin receptor substrate-1 (IRS-1) and IRS-2 are known to transduce and amplify signals emanating from the insulin receptor. Here we show that Grb2-associated binder 1 (Gab1), despite its structural similarity to IRS proteins, is a negative modulator of hepatic insulin action.
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