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Nature Medicine 10, 858-864 (1 August 2004) | doi:10.1038/nm1075;
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
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Abstract
The trafficking of circulating stem and progenitor cells to areas of tissue damage is poorly understood. The chemokine stromal cell–derived factor-1 (SDF-1 or CXCL12) mediates homing of stem cells to bone marrow by binding to CXCR4 on circulating cells.
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