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Nature Medicine 10, 739-743 (1 July 2004) | doi:10.1038/nm1071;
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
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Abstract
Leptin is an adipocyte-derived hormone that plays a key role in energy homeostasis, yet resistance to leptin is a feature of most cases of obesity in humans and rodents. In vitro analysis suggested that the suppressor of cytokine signaling-3 (Socs3) is a negative-feedback regulator of leptin signaling involved in leptin resistance.
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