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Nature Medicine 10, 484-486 (1 May 2004) | doi:10.1038/nm1042;
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
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Abstract
The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis.
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