Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Nature Medicine 10, 481-483 (1 May 2004) | doi:10.1038/nm1026;
Peroxisome proliferator|[ndash]|activated receptor-|[delta]| attenuates colon carcinogenesis
&
Abstract
Peroxisome proliferator–activated receptor-|[delta]| (PPAR-|[delta]|; also known as PPAR-β) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-|[delta]| in colon carcinogenesis using PPAR-|[delta]|-deficient (Ppard|[minus]|/|[minus]| ) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-|[delta]|. In contrast to previous reports suggesting that activation of PPAR-|[delta]| potentiates colon polyp formation, here we show that PPAR-|[delta]| attenuates colon carcinogenesis.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).