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Nature Medicine 14, 713-715 (1 July 2008) | doi:10.1038/nm0708-713;
Rejuvenating premature aging
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Abstract
New findings in this issue of Nature Medicine provide insight into a potential treatment for Hutchinson-Gilford progeria syndrome (HGPS), an extremely rare disease in which young children appear to age rapidly. The disease is caused by point mutations in the gene encoding the nuclear structural proteins lamin A and lamin C. As a result, lamin A becomes permanently farnesylated, a modification in which a farnesyl group is added to a protein.
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