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Nature Medicine 13, 673-674 (1 June 2007) | doi:10.1038/nm0607-673;

The hydrogen highway to reperfusion therapy

Katherine C Wood & Mark T Gladwin

Just when we thought we had exhausted our tool kit of therapeutic gases, Ohsawa et al. provide evidence that inhaled hydrogen gas (H2) has antioxidant and antiapoptotic activities that protect the brain against ischemia-reperfusion injury and stroke. During the ischemic phase of thromboembolic stroke, a blood clot travels to and lodges in the distal blood vessels in the brain, blocking blood flow to the oxygen-starved tissue for a period of hours.

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