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Nature Medicine 14, 485-487 (1 May 2008) | doi:10.1038/nm0508-485;
|[beta]|-adrenergic signaling in heart failure|[mdash]|adapt or die
Abstract
A report in this issue of Nature Medicine identifies a gene variant that seems to protect against the progression of heart failure. The gene, GRK5, encodes a G protein–coupled receptor kinase (GRK) that participates in signaling through β-adrenergic receptors, the targets of β-blockers.
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