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Nature Medicine 14, 372-373 (1 April 2008) | doi:10.1038/nm0408-372;
Robo4 counteracts VEGF signaling
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Abstract
In recent years, it has emerged that guidance cues responsible for neuronal development also have crucial roles in vessel formation and maturity. Many researchers have drawn a comparison between an actively developing axonal sprout and a newly forming blood vessel, as both migrate, elongate or retract in response to cues from surrounding tissues and matrix.
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