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Nature Medicine 14, 13-14 (1 January 2008) | doi:10.1038/nm0108-13;
Opening the gateway to tumors
Abstract
Why does the immune system help thwart tumor growth in some people with cancer but not in others? The work of Buckanvich et al. in this issue of Nature Medicine suggests that, at least for some of them, a molecular switch operates within the blood vessels of tumors to keep T lymphocytes out. Blocking or bypassing this switch can permit lymphocytes to enter tumors and destroy cancer cells in mouse models (Fig.
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