Review

Nature Clinical Practice Urology (2006) 3, 590-601
doi:10.1038/ncpuro0604  
Received 29 June 2006 | Accepted 14 August 2006

Mechanisms of Disease: the role of heat-shock protein 90 in genitourinary malignancy

Jean-Baptiste Lattouf, Ramaprasad Srinivasan, Peter A Pinto, W Marston Linehan and Leonard Neckers*

Correspondence *Urologic Oncology Branch, National Cancer Institute, Room 1-5942, Building 10 CRC, 9000 Rockville Pike, Bethesda, MD 20892, USA

Email neckersl@mail.nih.gov

Heat shock protein 90 (HSP90) plays a major role in many cancers, including tumors of the prostate and kidney. Its function in cell regulation makes it a potential target for treatments against cancer. This Review provides insights into the role of HSP90 in urologic cancers and discusses the data from clinical trials examining the use of HSP90 inhibitors in the treatment of patients with urologic cancers.

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