Tumor multifocality is associated with worse outcome in prostate cancer
Caroline Barranco
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Tumor grade is one of the most important prognostic factors for prostate cancer. Although the GLEASON SUM considers only the two largest (primary and secondary) neoplastic areas in the assessment of tumor grade, additional (tertiary) neoplasms can occur. Previous studies suggested that the presence of a tertiary neoplasm was associated with a poorer prognosis; a Dutch team has confirmed these results. Surprisingly, they found that the mere presence of a tertiary neoplasm, independent of its Gleason grade, is associated with a shorter time to PSA progression and worse outcome, and suggest that the contribution of tumor multifocality to prognosis is under-appreciated.
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